Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density.

Tytuł:: Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density.
Autorzy:: Hudson AG; Division of Cancer Epidemiology, Bureau for Public Health, West Virginia Department of Health and Human Resources, Charleston, West Virginia 25301-3715, USA. />Reeves KW
Modugno F
Wilson JW
Evans RW
Vogel VG
Gierach GL
Simpson J
Weissfeld JL
Źródło:: Nutrition and cancer [Nutr Cancer] 2013; Vol. 65 (3), pp. 410-6.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Publication: Philadelphia : Routledge
Original Publication: Philadelphia, Franklin Institute Press.
MeSH Terms:: Breast Neoplasms/*blood
Erythrocytes/*chemistry
Fatty Acids, Omega-3/*blood
Fatty Acids, Omega-6/*blood
Aged ; Arachidonic Acid/blood ; Body Mass Index ; Breast Density ; Docosahexaenoic Acids/blood ; Eicosapentaenoic Acid/blood ; Female ; Humans ; Mammary Glands, Human/abnormalities ; Middle Aged ; Postmenopause
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Grant Information:: R25-CA57703 United States CA NCI NIH HHS; K07-CA80668 United States CA NCI NIH HHS; M01 RR000056 United States RR NCRR NIH HHS; R21 CA095113 United States CA NCI NIH HHS; P20 CA103730-02 United States CA NCI NIH HHS; K07 CA080668 United States CA NCI NIH HHS; R21-CA95113 United States CA NCI NIH HHS; M01-RR000056 United States RR NCRR NIH HHS; P20 CA103730 United States CA NCI NIH HHS; R25 CA057703 United States CA NCI NIH HHS
Substance Nomenclature:: 0 (Fatty Acids, Omega-3)
0 (Fatty Acids, Omega-6)
25167-62-8 (Docosahexaenoic Acids)
27YG812J1I (Arachidonic Acid)
AAN7QOV9EA (Eicosapentaenoic Acid)
Entry Date(s):: Date Created: 20130328 Date Completed: 20130916 Latest Revision: 20211021
Update Code:: 20240104
PubMed Central ID:: PMC3657737
DOI:: 10.1080/01635581.2013.760744
PMID:: 23530640
: Czasopismo naukowe

Pełny tekst

Diets low in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and high in omega-3 (n-3) PUFAs may protect against breast cancer development. Associations of PUFA intake with mammographic density, an intermediate marker of breast cancer risk, have been inconsistent; however, prior studies have relied on self-reported dietary PUFA intake. We examined the association between circulating erythrocyte n-6 and n-3 PUFAs with mammographic density in 248 postmenopausal women who were not taking exogenous hormones. PUFAs in erythrocytes were measured by gas-liquid chromatography, and mammographic density was assessed quantitatively by planimetry. Spearman's correlation coefficients and generalized linear models were used to evaluate the relationships between PUFA measures and mammographic density. None of the erythrocyte n-6 or n-3 PUFA measures were associated with percent density or dense breast area.

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