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Tytuł:
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Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines.
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Autorzy:
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Nagel R; Department of Otolaryngology/Head-Neck Surgery, VU Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
Martens-de Kemp SR
Buijze M
Jacobs G
Braakhuis BJ
Brakenhoff RH
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Źródło:
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Oral oncology [Oral Oncol] 2013 Jun; Vol. 49 (6), pp. 560-6. Date of Electronic Publication: 2013 Apr 08.
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Typ publikacji:
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Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Oxford ; New York : Pergamon, c1997-
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MeSH Terms:
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Radiotherapy*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Carcinoma, Squamous Cell/*therapy
Head and Neck Neoplasms/*therapy
Papillomaviridae/*isolation & purification
Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Cell Line, Tumor ; Combined Modality Therapy ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/virology ; Humans ; Radiation Tolerance
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Entry Date(s):
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Date Created: 20130413 Date Completed: 20131206 Latest Revision: 20210105
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Update Code:
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20240104
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DOI:
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10.1016/j.oraloncology.2013.03.446
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PMID:
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23578372
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Objectives: Infection with the human papillomavirus (HPV) is an important risk factor for development of head and neck squamous cell carcinoma (HNSCC). Strikingly, HPV-positive HNSCCs have a more favorable prognosis than their HPV-negative counterparts. The current study was designed to explain this favorable prognosis of HPV-positive HNSCC.
Materials and Methods: This was performed by investigating the response of four HPV-positive and fourteen HPV-negative HNSCC cell lines to cisplatin, cetuximab and radiation.
Results: Analysis of the responses of this cell line panel indicated that HPV-positive cells are more resistant to cisplatin treatment than the HPV-negative HNSCCs, whereas the response to radiation and cetuximab did not differ.
Conclusions: The current study suggests that the favorable prognosis for patients with HPV-positive HNSCC does not seem to be related to an intrinsic sensitivity of these tumor cells to chemotherapy or radiation in vitro.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)