Changing the tune: plasticity and adaptation of retrograde signals.

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Abstrakt

Tytuł:: Changing the tune: plasticity and adaptation of retrograde signals.
Autorzy:: Iremonger KJ; Centre for Neuroendocrinology and Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
Wamsteeker Cusulin JI
Bains JS
Źródło:: Trends in neurosciences [Trends Neurosci] 2013 Aug; Vol. 36 (8), pp. 471-9. Date of Electronic Publication: 2013 May 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: Barking : Elsevier Applied Science Publishing
Original Publication: Amsterdam, New York, Elsevier/North-Holland Biomedical Press.
MeSH Terms:: Adaptation, Physiological/*physiology
Neuronal Plasticity/*physiology
Synaptic Transmission/*physiology
Animals ; Models, Neurological ; Signal Transduction/physiology
Grant Information:: Canada Canadian Institutes of Health Research
Contributed Indexing:: Keywords: dendrite; endocannabinoid; metaplasticity; plasticity; retrograde; synapse
Entry Date(s):: Date Created: 20130528 Date Completed: 20140618 Latest Revision: 20220309
Update Code:: 20240104
DOI:: 10.1016/j.tins.2013.04.007
PMID:: 23706151
: Czasopismo naukowe

Retrograde signaling is a fundamental means by which neurons communicate. The acceptance of this statement has required a revision of how we view transmission and storage of information at the synapse. Although there is a substantial body of literature on the diverse molecules that serve as retrograde signals, less is known about how retrograde signal capacity can be modified. Is retrograde signaling plastic? How does this plasticity manifest? Are there behavioral correlates that may bias a neuron towards 'changing its tune', retrogradely speaking, of course? Here, we review recent findings that retrograde signaling is a highly labile process that adds additional layers of complexity that must be untangled to understand information processing in the nervous system.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)

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