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Tytuł pozycji:

[An electromyographic study on the development of optimal tactics of botulinum toxin type A injections in children with spastic forms of cerebral palsy].

Tytuł :
[An electromyographic study on the development of optimal tactics of botulinum toxin type A injections in children with spastic forms of cerebral palsy].
Autorzy :
Kurenkov AL
Kuzenkova LM
Burgasova BI
Petrova SA
Klochkova OA
Nikitin SS
Artemenko AR
Mamed'iarov AM
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Źródło :
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2013; Vol. 113 (5 Pt 2), pp. 53-60.
Typ publikacji :
Comparative Study; English Abstract; Journal Article
Język :
Russian
Imprint Name(s) :
Publication: <1995->: Moskva : Media Sfera
Original Publication: Moskva : "Meditsina",
MeSH Terms :
Botulinum Toxins, Type A/*administration & dosage
Cerebral Palsy/*drug therapy
Electromyography/*methods
Muscle Contraction/*drug effects
Muscle Spasticity/*drug therapy
Muscle, Skeletal/*physiopathology
Practice Guidelines as Topic/*standards
Cerebral Palsy/complications ; Cerebral Palsy/physiopathology ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Injections, Intramuscular ; Leg/physiopathology ; Male ; Muscle Spasticity/etiology ; Muscle Spasticity/physiopathology ; Muscle, Skeletal/drug effects ; Neuromuscular Agents/administration & dosage ; Treatment Outcome
Substance Nomenclature :
0 (Neuromuscular Agents)
EC 3.4.24.69 (Botulinum Toxins, Type A)
Entry Date(s) :
Date Created: 20130607 Date Completed: 20130924 Latest Revision: 20161018
Update Code :
20201218
PMID :
23739515
Czasopismo naukowe
We studied 67 children, aged 2-9 years, with cerebral palsy including 56 children with a spastic form. An electromyographic method was used for the development of optimal tactics of botulinum toxin type A injections in different clinical presentations of spasticity. The best clinical results were obtained in children with the following changes on EMG: 1) the tonic muscle activity in resting state was minimal (<10 microvolts) and had local or regional distribution; 2) the pathological synkinetic activity during voluntary movements was minimal (synergetic activity coefficient for shin muscles was less than 0.45); 3) the disturbance of interactions between synergistic and antagonistic muscles was moderate (reciprocity coefficient was not less than 0.4); 4) EMG amplitude in voluntary muscle contraction should not be less than 150 microvolts. This approach to the treatment allowed to reach higher levels on The Gross Motor Function Classification System in part of children.

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