miR-124 controls male reproductive success in Drosophila.

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Abstrakt

Tytuł:: miR-124 controls male reproductive success in Drosophila.
Autorzy:: Weng R; Institute for Molecular and Cell Biology , Singapore , Singapore ; Department of Biological Sciences , National University of Singapore , Singapore , Singapore.
Chin JS
Yew JY
Bushati N
Cohen SM
Źródło:: ELife [Elife] 2013 Jun 11; Vol. 2, pp. e00640. Date of Electronic Publication: 2013 Jun 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
MeSH Terms:: MicroRNAs/*physiology
Reproduction/*physiology
Animals ; Female ; Male ; MicroRNAs/genetics ; Mutation ; Reproduction/genetics ; Sex Attractants/biosynthesis ; Sexual Behavior, Animal
References:: Cell. 2007 Oct 5;131(1):136-45. (PMID: 17923093)
Genetics. 1996 May;143(1):331-44. (PMID: 8722785)
Cell. 2012 Apr 27;149(3):515-24. (PMID: 22541426)
Nature. 2005 Nov 10;438(7065):229-33. (PMID: 16281036)
Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):249-54. (PMID: 22114190)
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5664-8. (PMID: 11960020)
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19577-82. (PMID: 18042702)
Learn Mem. 2005 Nov-Dec;12(6):636-45. (PMID: 16287720)
Cell. 1988 Jun 17;53(6):887-95. (PMID: 2454747)
RNA. 2004 Oct;10(10):1507-17. (PMID: 15383676)
Nat Neurosci. 2010 Apr;13(4):458-66. (PMID: 20305646)
Curr Opin Neurobiol. 2009 Apr;19(2):200-6. (PMID: 19541474)
Nat Neurosci. 2011 Jun;14(6):757-62. (PMID: 21516101)
Development. 2012 Apr;139(8):1427-34. (PMID: 22378639)
Nature. 2010 Jan 14;463(7278):227-31. (PMID: 19966787)
Neuron. 2008 Sep 11;59(5):759-69. (PMID: 18786359)
Genet Res. 2005 Aug;86(1):31-40. (PMID: 16181521)
Cell. 2012 May 25;149(5):1140-51. (PMID: 22632976)
PLoS Biol. 2010 May 04;8(5):e1000365. (PMID: 20454565)
PLoS Biol. 2010 Nov 23;8(11):e1000541. (PMID: 21124886)
Neuron. 2008 Sep 11;59(5):685-9. (PMID: 18786353)
Nature. 2007 Mar 29;446(7135):542-6. (PMID: 17392786)
Curr Biol. 2008 Apr 8;18(7):501-6. (PMID: 18394895)
Curr Opin Neurobiol. 2010 Dec;20(6):770-5. (PMID: 20833534)
Cell. 2005 Jun 3;121(5):785-94. (PMID: 15935764)
Behav Genet. 1984 Sep;14(5):441-78. (PMID: 6441563)
Nature. 1993 Mar 11;362(6416):171-5. (PMID: 7680770)
Annu Rev Genet. 1996;30:637-702. (PMID: 8982468)
Annu Rev Genet. 1983;17:345-93. (PMID: 6421227)
Behav Genet. 1978 Mar;8(2):125-41. (PMID: 99136)
Genes Dev. 2010 Jul 1;24(13):1339-44. (PMID: 20595229)
PLoS Biol. 2005 Mar;3(3):e85. (PMID: 15723116)
Front Endocrinol (Lausanne). 2011 Oct 10;2:46. (PMID: 22654810)
Genetics. 1988 Jul;119(3):639-46. (PMID: 3136054)
Curr Biol. 2012 Jul 10;22(13):1155-65. (PMID: 22658598)
Evolution. 1987 Mar;41(2):294-302. (PMID: 28568760)
Cell. 1996 Dec 13;87(6):1079-89. (PMID: 8978612)
J Chem Ecol. 1985 Dec;11(12):1617-29. (PMID: 24311330)
Genes Dev. 1996 Aug 15;10(16):2089-101. (PMID: 8769651)
Cell Rep. 2012 Jun 28;1(6):599-607. (PMID: 22813735)
Methods Mol Biol. 2011;732:99-120. (PMID: 21431708)
Cell. 2005 Dec 16;123(6):1133-46. (PMID: 16337999)
Nat Neurosci. 2006 Dec;9(12):1469-71. (PMID: 17115036)
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16550-7. (PMID: 16179386)
Integr Zool. 2007 Jun;2(2):89-99. (PMID: 21396023)
Curr Biol. 2009 Aug 11;19(15):1245-54. (PMID: 19615904)
Cell. 1989 Mar 24;56(6):997-1010. (PMID: 2493994)
Proc Biol Sci. 1996 Aug 22;263(1373):967-73. (PMID: 8805834)
Genes Dev. 2009 Feb 15;23(4):466-81. (PMID: 19240133)
Genetics. 1999 Aug;152(4):1653-67. (PMID: 10430590)
Genetics. 1996 Dec;144(4):1577-87. (PMID: 8978046)
Nature. 2005 Jul 21;436(7049):395-400. (PMID: 15959468)
Nature. 2009 Oct 15;461(7266):987-91. (PMID: 19829381)
Contributed Indexing:: Keywords: D. melanogaster; behaviour; evolution; genetics; microRNA; pheromome; selection
Note: Original DateCompleted: 20130726 Note: Original DateCompleted: 20140206
Substance Nomenclature:: 0 (MIRN124 microRNA, Drosophila)
0 (MicroRNAs)
0 (Sex Attractants)
Entry Date(s):: Date Created: 20130625 Date Completed: 20150423 Latest Revision: 20220309
Update Code:: 20240104
PubMed Central ID:: PMC3679528
DOI:: 10.7554/eLife.00640
PMID:: 23795292
: Czasopismo naukowe

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Many aspects of social behavior are controlled by sex-specific pheromones. Gender-appropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of gender-appropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. DOI:http://dx.doi.org/10.7554/eLife.00640.001.

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