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Tytuł pozycji:

Decreases in inflammatory and coagulation biomarkers levels in HIV-infected patients switching from enfuvirtide to raltegravir: ANRS 138 substudy.

Tytuł:
Decreases in inflammatory and coagulation biomarkers levels in HIV-infected patients switching from enfuvirtide to raltegravir: ANRS 138 substudy.
Autorzy:
Silva EF; Department of Infectious Diseases, AP-HP, Hôpital Saint Louis, University of Paris Diderot Paris, France.
Charreau I
Gourmel B
Mourah S
Kalidi I
Guillon B
De Castro N
Caron F
Braun J
Molina JM
Corporate Authors:
ANRS 138 EASIER Study Group
Źródło:
The Journal of infectious diseases [J Infect Dis] 2013 Sep; Vol. 208 (6), pp. 892-7. Date of Electronic Publication: 2013 Jun 24.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
MeSH Terms:
Biomarkers/*blood
Blood Coagulation/*drug effects
HIV Envelope Protein gp41/*therapeutic use
HIV Infections/*drug therapy
Inflammation/*blood
Peptide Fragments/*therapeutic use
Pyrrolidinones/*therapeutic use
Adult ; Anti-HIV Agents/therapeutic use ; C-Reactive Protein/analysis ; CD4 Lymphocyte Count ; Enfuvirtide ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; HIV Infections/blood ; HIV Infections/virology ; HIV-1 ; Humans ; Inflammation/virology ; Interleukin-6/blood ; Male ; Middle Aged ; RNA, Viral/blood ; Raltegravir Potassium ; Specimen Handling ; Viral Load
Contributed Indexing:
Investigator: A Arulananthan; M Barlot; A Bouchibti; J Braun; R Chrestia-Blanchine; V Eliette; F Euphrasie; V Foubert; I Fournier; B Guillon; S Leonardo; V Meiffredy; E Moreau; A Polaert; P Ralaimazava; J Minjoz; Gil; Essert; Lucht; Fresard; Rona; Hoen; Foltzer; Genton; Bettinger; Dupon; Raymond; Pinson; Ghezzoul; Viard; Coignard; Dhooge; Duvivier; Obenga; Maignan; Broissand; Chaix; Ghosn; Brunet; Bechara; Chaix; Gellen-Dautremer; Duracinsky; Peretti; Quertainmont; Rannou; Hosten; Pallier; Lafeuillade; Allemand-Sourrieu; Cheret; Hittinger; Lambry; Danielli; Philip; Caharel; Poggi; de Truchis; Berthe; Lagarde; Bouchand; Mathez; Slama; Chakvetadze; Fontaine; Guessant; Assami; Boué; Chambrin; Bornarel; Stralka; Ingrand; Weiss; Buisson; Eliaszewicz; Karmochkine; Kousignian; Piketty; Tegna; Rousseau; Tisserand; Salmon-Ceron; Tahi; Guerin; Krivine; Levy; Bamogho; Berdah; Bourdillon; Melica; Chesnel; Jaccoulet; Dauvillier; Katlama; A Mohand; Caby; Ktorza; Valantin; Curjol; Simon; Breton; Iguertsira; Vergnoux; B Senhadj; Soulie; Saint-Antoine; Meynard; Bollens; Lefebvre; Ouazene; Desplanque; Daguenel-Nguyen; Harchi; Aslan; Bouldouyre; C de Verdière; de Castro; Denis; Ferret; Gallien; Gerard; Goguel; Kandel; Lafaurie; Lascoux-Combe; Lagrange; Martinez; Molina; Parlier; Pavie; Pintado; Rachline; Rozenbaum; Salliot; Taulera; Bourge; Delgado; Loze; Schnell-Niedbalski; Waquet; Mezreb; Palmer; Mourez; Chennebault; Loison; Daniel; Ducancelle; Morlat; Bonnet; Gellie; Lacoste; Louis; Pedeboscq; Pinson; Ragnaud; Cazane; Neau; Raymond; Dupin; Jeanblanc; Carbonnel; Chiarello; Livrozet; Makhloufi-Chakir; Pivot; Le Thi; Cotte; Augustin-Normand; Bailly; Koffi; Lebouché; Miailhes; Schlienger; Brochier; ThoirainSantos-Antao; Le Thi; Poizot-Martin; Drogoul; Faucher; Menard; Peyrouse; Fabre; Penot-Ragon; Tamalet; Yeni; el A Talbi; Palhavan; Fraqueiro; Tandia; Alexandre; Reynes; Atoui; Cheval; Jacquet; L Falher; L Moing; Makinson; Md Boever; Thomas; Tramoni; Castet; Montes; Raffi; Allavena; Besnier; Billaud; Bonnet; Bouchez; Boutoille; Launay; Mounoury; Point; Reliquet; Michele; Hue; Flet; Ferre; Michele; Ratajczak-Enselme; Besnier; Tourdjam; Soufflet; Bansart; Dubost; Gaudy-Graffin; Marchou; Khatibi; Labau; Balsarin; Barone; Peyranne; Nicot; C de Narce; Verdon; Dargere; de La Blanchardiere; Gras; Martin; Feret; Texier; Vabret; Piroth; Buisson; Duong; Grappin; Martha; Waldner; Braconnier; Ttreuvelot; Saliques; Cuisenier; Chavanet; Yazdanpanah; Aissi; Ajana; Alcaraz; Baclet; de La Tribonniere; Melliez; Pavel; Valette; Dubar; Taillet; B Chu; May; Boyer; Burty; Deguis; Herault; Lecompte; Lichosik; Wasspombou; Demore; Venard; Debad; Donnadieu; de Patureaux; Rlharrar; Richier; Thebault; Goguelin; Gilquin; Chassaing; Cros; Phan Thi; Tersen; Nguyen; Beck-Wirth; Benomar; Berg; Issac
Keywords: CRP; D-dimer; HIV; IL-6; biomarkers; enfuvirtide; raltegravir; switch
Substance Nomenclature:
0 (Anti-HIV Agents)
0 (Biomarkers)
0 (Fibrin Fibrinogen Degradation Products)
0 (HIV Envelope Protein gp41)
0 (Interleukin-6)
0 (Peptide Fragments)
0 (Pyrrolidinones)
0 (RNA, Viral)
0 (fibrin fragment D)
19OWO1T3ZE (Enfuvirtide)
43Y000U234 (Raltegravir Potassium)
9007-41-4 (C-Reactive Protein)
Entry Date(s):
Date Created: 20130627 Date Completed: 20131104 Latest Revision: 20181202
Update Code:
20240104
DOI:
10.1093/infdis/jit280
PMID:
23801606
Czasopismo naukowe
Stored plasma specimens from 164 participants in the ANRS 138 trial were analyzed to determine interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels at baseline and weeks 24 and 48. These virologically suppressed, treatment-experienced patients were randomly assigned to undergo an immediate switch (IS) or a deferred switch (DS; at week 24) from an enfuvirtide-based antiretroviral therapy (ART) regimen to a raltegravir-based regimen. At week 24, a significant decrease from baseline was observed in the IS arm, compared with the DS arm, for IL-6 level (-30% vs +10%; P < .002), hsCRP level (-46% vs +15%; P < .0001), and D-dimer level (-40% vs +6%; P < .0001). At week 48, there was a reproducible decrease in levels of all biomarkers in the DS arm.

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