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Tytuł:
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VEGF plasma level variations in duloxetine-treated patients with major depression.
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Autorzy:
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Fornaro M; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy; Scienze della Formazione, University of Catania, Catania, Italy. Electronic address: .
Rocchi G; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy. Electronic address: .
Escelsior A; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy. Electronic address: .
Contini P; Department of Internal Medicine, Section of Immunology, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: .
Ghio M; Department of Internal Medicine, Section of Immunology, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: .
Colicchio S; Department of Neurosciences, Catholic University, Rome, Italy. Electronic address: .
De Berardis D; Department of Neuroscience and Imaging, Chair of Psychiatry, University of Chieti, Chieti, Italy. Electronic address: .
Amore M; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy. Electronic address: .
Fornaro P; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy. Electronic address: .
Martino M; Department of Neuroscience, Section of Psychiatry, IRCCS AOU San Martino-IST, Genoa 16100, Italy. Electronic address: .
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Źródło:
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Journal of affective disorders [J Affect Disord] 2013 Nov; Vol. 151 (2), pp. 590-595. Date of Electronic Publication: 2013 Jul 18.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
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MeSH Terms:
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Antidepressive Agents/*therapeutic use
Depressive Disorder, Major/*drug therapy
Thiophenes/*therapeutic use
Vascular Endothelial Growth Factor A/*blood
Adult ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/physiopathology ; Duloxetine Hydrochloride ; Female ; Humans ; Male ; Middle Aged
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Contributed Indexing:
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Keywords: Depression; Duloxetine; Neurovascular unit; VEGF
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Substance Nomenclature:
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0 (Antidepressive Agents)
0 (Thiophenes)
0 (Vascular Endothelial Growth Factor A)
9044SC542W (Duloxetine Hydrochloride)
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Entry Date(s):
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Date Created: 20130723 Date Completed: 20140513 Latest Revision: 20201206
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Update Code:
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20240104
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DOI:
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10.1016/j.jad.2013.06.055
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PMID:
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23871390
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Background: The vascular endothelial growth factor (VEGF) signaling, which modulates angiogenesis and neurogenesis within the neurovascular unit, might play an important role in the neuro-endocrine-immune (NEI) stress-adaptation system. Recent evidence suggests that VEGF is involved in the pathophysiology of a number of diseases including major depressive disorder (MDD) and is affected by some treatments, including antidepressants. The objective of the study was to investigate the VEGF level variations in MDD patients during antidepressant treatment with duloxetine, a relatively new SNRI.
Methods: A total of 30 MDD patients and 32 healthy controls were assessed using the Hamilton Depression Scale (HAM-D) and monitored for VEGF plasma levels at baseline, week 6 and week 12 of duloxetine treatment (60 mg/day) and at baseline, respectively.
Results: According to early clinical response to duloxetine (defined at week 6 by reduction>50% of baseline HAM-D score), the MDD patients were divided into early responders (ER) and early non-responders (ENR). During duloxetine treatment, we found an opposite trend in the VEGF levels between ER and ENR: in ER the VEGF levels significantly increased in association with clinical response at W6, while in ENR the VEGF levels significantly decreased in association with an overall clinical response at W12.
Limitations: Small sample size.
Conclusions: The opposite trends in VEGF levels, increasing in ER and decreasing in ENR, might reflect differential Norepinephrine/Serotonin effects of duloxetine on differential neurobiological backgrounds of depressive syndromes. Overall, the modulation of VEGF signaling within the neurovascular unit during antidepressant treatment could hypothetically favor the remodeling of neural circuitry, contributing to adaptive adjustment of the NEI stress-adaptation system.
(© 2013 Elsevier B.V. All rights reserved.)
