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Tytuł:
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Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster.
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Autorzy:
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Kugler JM; Institute of Molecular and Cell Biology, Singapore 138673, Republic of Singapore.
Chen YW
Weng R
Cohen SM
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Źródło:
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G3 (Bethesda, Md.) [G3 (Bethesda)] 2013 Sep 04; Vol. 3 (9), pp. 1573-6. Date of Electronic Publication: 2013 Sep 04.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Bethesda, MD : Genetics Society of America, 2011-
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MeSH Terms:
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Drosophila melanogaster/*genetics
Germ Cells/*cytology
MicroRNAs/*genetics
Animals ; Drosophila melanogaster/growth & development ; Embryo, Nonmammalian/metabolism ; Female ; Genotype ; MicroRNAs/metabolism ; Mutation ; Phenotype
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References:
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Contributed Indexing:
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Keywords: microRNA; phenotypic trait variance; primordial germ cell development
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Substance Nomenclature:
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0 (MicroRNAs)
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Entry Date(s):
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Date Created: 20130730 Date Completed: 20140418 Latest Revision: 20211021
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Update Code:
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20240104
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PubMed Central ID:
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PMC3755917
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DOI:
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10.1534/g3.113.007591
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PMID:
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23893743
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MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression that may act as buffering agents to stabilize gene-regulatory networks. Here, we identify two miRNAs that are maternally required for normal embryonic primordial germ cell development in Drosophila melanogaster. Embryos derived from miR-969 and miR-9c mutant mothers had, on average, reduced germ cell numbers. Intriguingly, this reduction correlated with an increase in the variance of this quantitative phenotypic trait. Analysis of an independent set of maternal mutant genotypes suggests that reduction of germ cell number need not lead to increased variance. Our observations are consistent with the hypothesis that miR-969 and miR-9c contribute to stabilizing the processes that control germ number, supporting phenotypic robustness.