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Tytuł:
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Longitudinal changes in viral RNA concentration in patients with chronic hepatitis C and/or HIV infection in the absence of antiviral therapy.
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Autorzy:
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Barreiro P; Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. Electronic address: .
Labarga P
Fernández-Montero JV
Poveda E
de Mendoza C
Sánchez C
Vispo E
Soriano V
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Źródło:
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2013 Oct; Vol. 58 (2), pp. 391-5. Date of Electronic Publication: 2013 Jul 30.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier Science, c1998-
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MeSH Terms:
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Viral Load*
HIV/*isolation & purification
HIV Infections/*virology
Hepacivirus/*isolation & purification
Hepatitis C, Chronic/*virology
RNA, Viral/*blood
Adult ; Aged ; Female ; HIV Infections/complications ; Hepatitis C, Chronic/complications ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Retrospective Studies
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Contributed Indexing:
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Keywords: Antiviral therapy; HCV; HIV; Hepatitis C; Viral load
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Substance Nomenclature:
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0 (RNA, Viral)
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Entry Date(s):
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Date Created: 20130806 Date Completed: 20140418 Latest Revision: 20130930
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Update Code:
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20240104
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DOI:
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10.1016/j.jcv.2013.06.031
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PMID:
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23910933
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Background: The concentration of circulating viral RNA at baseline and during antiviral therapy predicts response in both HIV infection and chronic hepatitis C.
Methods: Retrospective review of longitudinal plasma HCV-RNA determinations in untreated chronic hepatitis C patients. As comparison, longitudinal plasma HIV-RNA measurements were performed in untreated HIV individuals.
Results: A total of 3169 HCV-RNA determinations over 43.0±31.6 months were available for 818 chronic hepatitis C patients. For 333 HIV individuals, 1998 HIV-RNA measurements were examined over 27.3±17.5 months. Overall 44% consecutive specimens had >0.5 log variation in HCV-RNA values compared to 23% for HIV-RNA (p<0.001). These rates were 15% and 4%, respectively, for variations >1 log (p<0.001). In multivariate analysis (odds ratio, 95% confidence interval, p), the likelihood of experiencing HCV-RNA variations >0.5 log IU/mL was greater in patients with lower HCV-RNA (0.35 per log[0.26-0.47], 0.001), HIV coinfection (2.57[91.56-4.23], <0.001) and IL28B-CC (1.87[1.28-2.74], 0.001).
Conclusions: Fluctuation in circulating HCV-RNA may be clinically meaningful in a substantial proportion of chronic hepatitis C patients. It may influence the best time to prescribe antiviral therapy. Moreover, decisions based on early viral kinetics, such as early stopping rules, may require testing of baseline specimens the closest to treatment initiation.
(Copyright © 2013 Elsevier B.V. All rights reserved.)
