Lack of an association between CYP11B2 C-344T gene polymorphism and ischemic stroke: a meta-analysis of 7,710 subjects.

Szczegóły
Abstrakt

Tytuł:: Lack of an association between CYP11B2 C-344T gene polymorphism and ischemic stroke: a meta-analysis of 7,710 subjects.
Autorzy:: Pi Y; Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Zhang LL
Chang K
Guo L
Liu Y
Li BH
Cao XJ
Liao SQ
Gao CY
Li JC
Źródło:: PloS one [PLoS One] 2013 Aug 08; Vol. 8 (8), pp. e68842. Date of Electronic Publication: 2013 Aug 08 (Print Publication: 2013).
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Polymorphism, Single Nucleotide*
Cytochrome P-450 CYP11B2/*genetics
Stroke/*genetics
Adult ; Aged ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Models, Genetic
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Substance Nomenclature:: EC 1.14.15.4 (Cytochrome P-450 CYP11B2)
Entry Date(s):: Date Created: 20130817 Date Completed: 20140430 Latest Revision: 20211021
Update Code:: 20240104
PubMed Central ID:: PMC3738569
DOI:: 10.1371/journal.pone.0068842
PMID:: 23950878
: Czasopismo naukowe

Pełny tekst

Background: The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed.
Methods: Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test.
Results: A total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95-1.49; additive model: OR = 1.43, 95% CI = 0.91-2.27; dominant model: OR = 1.30, 95% CI = 0.89-1.89; and recessive model: OR = 1.24, 95% CI = 0.96-1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87-1.32; additive model: OR = 1.15, 95% CI = 0.77-1.71; dominant model: OR = 1.13, 95% CI = 0.92-1.38; and recessive model: OR = 1.09, 95% CI = 0.84-1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90-2.76; additive model: OR = 2.37, 95% CI = 0.79-7.05; dominant model: OR = 1.79, 95% CI = 0.77-4.19; and recessive model: OR = 1.80, 95% CI = 0.96-3.36).
Conclusion: The present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.

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