Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.

Tytuł:: Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.
Autorzy:: Ramsey KA; Division of Clinical Sciences, Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia.
Foong RE
Sly PD
Larcombe AN
Zosky GR
Źródło:: Environmental health perspectives [Environ Health Perspect] 2013 Oct; Vol. 121 (10), pp. 1187-93. Date of Electronic Publication: 2013 Aug 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
MeSH Terms:: Arsenic/*toxicity
Arsenic Poisoning/*physiopathology
Environmental Exposure/*adverse effects
Influenza, Human/*physiopathology
Lung/*drug effects
Respiratory Tract Infections/*physiopathology
Animals ; Arsenic Poisoning/complications ; Bronchiectasis/physiopathology ; Female ; Humans ; Male ; Mice, Inbred C57BL ; Pregnancy ; Respiratory Tract Infections/etiology
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Substance Nomenclature:: N712M78A8G (Arsenic)
Entry Date(s):: Date Created: 20130824 Date Completed: 20140508 Latest Revision: 20211021
Update Code:: 20240104
PubMed Central ID:: PMC3801203
DOI:: 10.1289/ehp.1306748
PMID:: 23968752
: Czasopismo naukowe

Pełny tekst

Background: Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood.
Objective: We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice.
Methods: C57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function.
Results: Early life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure.
Conclusions: Increased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.

Comment in: Environ Health Perspect. 2013 Oct;121(10):A312. (PMID: 24218665)

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