-
Tytuł:
-
Oral HPV infection and persistence in patients with head and neck cancer.
-
Autorzy:
-
Morbini P; Department of Molecular Medicine, Unit of Pathology, University of Pavia, Pavia, Italy; Department of Pathology IRCCS Policlinico S. Matteo Foundation, Pavia, Italy. Electronic address: .
Dal Bello B
Alberizzi P
Mannarini L
Mevio N
Garotta M
Mura F
Tinelli C
Bertino G
Benazzo M
-
Źródło:
-
Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2013 Oct; Vol. 116 (4), pp. 474-84.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: New York, NY : Elsevier
-
MeSH Terms:
-
Carcinoma, Squamous Cell/*complications
Cyclin-Dependent Kinase Inhibitor p16/*analysis
DNA, Viral/*analysis
Head and Neck Neoplasms/*complications
Mouth Mucosa/*pathology
Papillomaviridae/*genetics
Papillomavirus Infections/*complications
Aged ; Carcinoma, Squamous Cell/virology ; Case-Control Studies ; DNA, Viral/genetics ; Female ; Genotype ; Head and Neck Neoplasms/virology ; Humans ; In Situ Hybridization ; Logistic Models ; Male ; Middle Aged ; Mouth Mucosa/virology ; Papillomavirus Infections/genetics ; Papillomavirus Infections/virology ; Prognosis ; Proportional Hazards Models ; Recurrence ; Risk
-
Substance Nomenclature:
-
0 (Cyclin-Dependent Kinase Inhibitor p16)
0 (DNA, Viral)
-
Entry Date(s):
-
Date Created: 20130917 Date Completed: 20140522 Latest Revision: 20130916
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.oooo.2013.06.019
-
PMID:
-
24035114
-
Objective: To investigate the presence and persistence of human papillomavirus (HPV) infection in the oral mucosa of patients with head and neck squamous cell carcinoma (HNSCC), and its correlation with prognosis.
Study Design: HPV infection was characterized in tumors and pre and posttreatment oral scrapings in 51 patients with HNSCC and matched controls using the SPF10 LiPA Extra assay. p16INK4A immunostain and in situ hybridization for high-risk HPV genotypes recognized transcriptionally active infection in tumor samples. The risk of infection was compared in patients and controls. The association of pretreatment HPV status with recurrence and survival and with posttreatment HPV persistence was assessed.
Results: Oral HPV infection risk was significantly higher in patients with HNSCC than in controls (P < .001). Oral HPV infection was associated with infection in the first posttreatment scrapings (P = .015), but did not affect recurrence or prognosis.
Conclusion: Oral HPV infection is frequent in patients with HNSCC and has no prognostic implications, suggesting that posttreatment polymerase chain reaction monitoring on oral cells is not effective to monitor patient recurrence risk.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
