Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.

Tytuł:: Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.
Autorzy:: Wu XJ; Department of Radiation Oncology, The First People's Hospital of Xuzhou, China.
Mi YY
Yang H
Hu AK
Li C
Li XD
Zhang QG
Źródło:: Onkologie [Onkologie] 2013; Vol. 36 (10), pp. 573-6. Date of Electronic Publication: 2013 Sep 17.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, New York, Karger.
MeSH Terms:: Genetic Markers/*genetics
Genetic Predisposition to Disease/*epidemiology
Genetic Predisposition to Disease/*genetics
MicroRNAs/*genetics
Polymorphism, Single Nucleotide/*genetics
Stomach Neoplasms/*epidemiology
Stomach Neoplasms/*genetics
Aged ; Aged, 80 and over ; China/epidemiology ; Female ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Assessment
Substance Nomenclature:: 0 (Genetic Markers)
0 (MIRN499 microRNA, human)
0 (MicroRNAs)
Entry Date(s):: Date Created: 20131011 Date Completed: 20140604 Latest Revision: 20220410
Update Code:: 20240104
DOI:: 10.1159/000355518
PMID:: 24107911
: Czasopismo naukowe

Pełny tekst

Background: Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population.
Patients and Methods: The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results: There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes.
Conclusion: The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.
(© 2013 S. Karger GmbH, Freiburg.)

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