KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.

Szczegóły
Abstrakt

Tytuł:: KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.
Autorzy:: Hoshino H; Section of Pathophysiology and Neurobiology, Research, National Center for Geriatrics and Gerontology, (HH, SO, KU), Obu, Japan.
Foyez T
Ohtake-Niimi S
Takeda-Uchimura Y
Michikawa M
Kadomatsu K
Uchimura K
Źródło:: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2014 Feb; Vol. 62 (2), pp. 145-56. Date of Electronic Publication: 2013 Oct 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2011->: Thousand Oaks, CA : SAGE Publications
Original Publication: Baltimore : Williams & Wilkins Co., c1953-
MeSH Terms:: Brain/*metabolism
Galactose/*metabolism
Keratan Sulfate/*metabolism
Sulfotransferases/*metabolism
Animals ; Animals, Newborn ; Brain/growth & development ; HeLa Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Messenger/metabolism ; Sulfotransferases/genetics ; Time Factors ; Carbohydrate Sulfotransferases
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Contributed Indexing:: Keywords: 5D4; developing brain; extracellular matrix; glycosaminoglycan; keratan sulfate; phosphacan; sulfotransferase
Substance Nomenclature:: 0 (RNA, Messenger)
9056-36-4 (Keratan Sulfate)
EC 2.8.2.- (Sulfotransferases)
X2RN3Q8DNE (Galactose)
Entry Date(s):: Date Created: 20131025 Date Completed: 20140318 Latest Revision: 20231213
Update Code:: 20240104
PubMed Central ID:: PMC3902094
DOI:: 10.1369/0022155413511619
PMID:: 24152993
: Czasopismo naukowe

Keratan sulfate (KS) comprises repeating disaccharides of galactose (Gal) and N-acetylglucosamine (GlcNAc). Residues of Gal and GlcNAc in KS are potentially modified with sulfate at their C-6 positions. The 5D4 monoclonal antibody recognizes KS structures containing Gal and GlcNAc, both 6-sulfated, and has been used most extensively to evaluate KS expression in mammalian brains. We previously showed that GlcNAc6ST1 is an enzyme responsible for the synthesis of the 5D4 epitope in developing brain and in the adult brain, where it is induced after injury. It has been unclear which sulfotransferase is responsible for Gal-6-sulfation within the 5D4 KS epitope in developing brains. We produced mice deficient in KSGal6ST, a Gal-6-sulfotransferase. Western blotting and immunoprecipitation revealed that all 5D4-immunoreactivity to proteins, including phosphacan, were abolished in KSGal6ST-deficient postnatal brains. Likewise, the 5D4 epitope, expressed primarily in the cortical marginal zone and subplate and dorsal thalamus, was eliminated in KSGal6ST-deficient mice. Disaccharide analysis showed the loss of Gal-6-sulfate in KS of the KSGal6ST-deficient brains. Transfection studies revealed that GlcNAc6ST1 and KSGal6ST cooperated in the expression of the 5D4 KS epitope in HeLa cells. These results indicate that KSGal6ST is essential for C-6 sulfation of Gal within KS in early postnatal brains.

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