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Tytuł pozycji:

Effects of experimental desynchronosis on the organs of immune system in WAG and ISIAH rats.

Tytuł :
Effects of experimental desynchronosis on the organs of immune system in WAG and ISIAH rats.
Autorzy :
Shurlygina AV; Institute of Physiology, Siberian Branch of Russian Academy of Sciences; Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. .
Melnikova EV
Panteleeva NG
Tenditnik MV
Dushkin MI
Khrapova MV
Trufakin VA
Pokaż więcej
Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Sep; Vol. 155 (5), pp. 659-62.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
MeSH Terms :
Circadian Rhythm/*immunology
Hypertension/*pathology
Immune System/*pathology
Spleen/*pathology
Thymus Gland/*pathology
Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/pathology ; Antigen-Presenting Cells/radiation effects ; Antigens, CD/genetics ; Antigens, CD/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; B-Lymphocytes/radiation effects ; Blood Pressure ; Cell Differentiation ; Gene Expression ; Hypertension/immunology ; Immune System/immunology ; Immune System/radiation effects ; Inflammation/immunology ; Inflammation/pathology ; Light ; Male ; Photoperiod ; Rats ; Spleen/immunology ; Spleen/radiation effects ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes/radiation effects ; Thymus Gland/immunology ; Thymus Gland/radiation effects
Substance Nomenclature :
0 (Antigens, CD)
Entry Date(s) :
Date Created: 20131130 Date Completed: 20140708 Latest Revision: 20190813
Update Code :
20210210
DOI :
10.1007/s10517-013-2219-9
PMID :
24288733
Czasopismo naukowe
We studied the influence of abnormal illumination regimen on cell composition of the central and peripheral organs of the immune system in ISIAH rats and control WAG rats. In ISIAH rats, 24-h illumination for 14 days led to more pronounced inhibition of cell proliferation and differentiation in the thymus and more pronounced decrease in splenocyte proliferation and T and B cell counts in the spleen in comparison with WAG rats; however, the level of antigen-presenting cells in the spleen of ISIAH increased. We concluded that ISIAH rats are more sensitive to abnormal illumination regimen than WAG rats. Twenty-four-hour illumination was associated with impairments of central differentiation of T cells and activation of systemic inflammation followed by impairment of differentiation regulation, which can aggravate metabolic dysfunctions in these animals.

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