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Tytuł pozycji:

What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial.

Tytuł:
What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial.
Autorzy:
de Oliveira AR
Vanin AA
De Marchi T
Antonialli FC
Grandinetti Vdos S
de Paiva PR
Albuquerque Pontes GM
Santos LA
Aleixo Junior Ide O
de Carvalho Pde T
Bjordal JM
Leal-Junior EC; Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, São Paulo, SP 01504-001, Brazil. .
Źródło:
Trials [Trials] 2014 Feb 27; Vol. 15, pp. 69. Date of Electronic Publication: 2014 Feb 27.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [London] : BioMed Central, 2006-
MeSH Terms:
Exercise*
Radiation Dosage*
Research Design*
Low-Level Light Therapy/*methods
Muscle Contraction/*radiation effects
Muscle Fatigue/*radiation effects
Muscle, Skeletal/*radiation effects
Biomarkers/metabolism ; Biomechanical Phenomena ; Brazil ; Clinical Protocols ; Double-Blind Method ; Humans ; Inflammation Mediators/metabolism ; Male ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiopathology ; Oxidative Stress ; Recovery of Function ; Time Factors ; Treatment Outcome
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Molecular Sequence:
ClinicalTrials.gov NCT01844271
Substance Nomenclature:
0 (Biomarkers)
0 (Inflammation Mediators)
Entry Date(s):
Date Created: 20140301 Date Completed: 20141021 Latest Revision: 20211021
Update Code:
20240104
PubMed Central ID:
PMC3944795
DOI:
10.1186/1745-6215-15-69
PMID:
24576321
Czasopismo naukowe
Background: Recent studies involving phototherapy applied prior to exercise have demonstrated positive results regarding the attenuation of muscle fatigue and the expression of biochemical markers associated with recovery. However, a number of factors remain unknown, such as the ideal dose and application parameters, mechanisms of action and long-term effects on muscle recovery. The aims of the proposed project are to evaluate the long-term effects of low-level laser therapy on post-exercise musculoskeletal recovery and identify the best dose andapplication power/irradiation time.
Design and Methods: A double-blind, randomized, placebo-controlled clinical trial with be conducted. After fulfilling the eligibility criteria, 28 high-performance athletes will be allocated to four groups of seven volunteers each. In phase 1, the laser power will be 200 mW and different doses will be tested: Group A (2 J), Group B (6 J), Group C (10 J) and Group D (0 J). In phase 2, the best dose obtained in phase 1 will be used with the same distribution of the volunteers, but with different powers: Group A (100 mW), Group B (200 mW), Group C (400 mW) and Group D (0 mW). The isokinetic test will be performed based on maximum voluntary contraction prior to the application of the laser and after the eccentric contraction protocol, which will also be performed using the isokinetic dynamometer. The following variables related to physical performance will be analyzed: peak torque/maximum voluntary contraction, delayed onset muscle soreness (algometer), biochemical markers of muscle damage, inflammation and oxidative stress.
Discussion: Our intention, is to determine optimal laser therapy application parameters capable of slowing down the physiological muscle fatigue process, reducing injuries or micro-injuries in skeletal muscle stemming from physical exertion and accelerating post-exercise muscle recovery. We believe that, unlike drug therapy, LLLT has a biphasic dose-response pattern.
Trial Registration: The protocol for this study is registered with the Protocol Registry System, ClinicalTrials.gov identifier NCT01844271.

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