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Tytuł pozycji:

Increased skeletal muscle capillarization after aerobic exercise training and weight loss improves insulin sensitivity in adults with IGT.

Tytuł :
Increased skeletal muscle capillarization after aerobic exercise training and weight loss improves insulin sensitivity in adults with IGT.
Autorzy :
Prior SJ; Corresponding author: Steven J. Prior, .
Blumenthal JB
Katzel LI
Goldberg AP
Ryan AS
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Źródło :
Diabetes care [Diabetes Care] 2014 May; Vol. 37 (5), pp. 1469-75. Date of Electronic Publication: 2014 Mar 04.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn.
MeSH Terms :
Neovascularization, Physiologic*
Glucose Intolerance/*physiopathology
Insulin Resistance/*physiology
Muscle, Skeletal/*blood supply
Obesity/*physiopathology
Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; Body Composition/physiology ; Exercise/physiology ; Female ; Glucose Clamp Technique ; Glucose Tolerance Test ; Humans ; Insulin/metabolism ; Male ; Microvessels/physiology ; Middle Aged ; Overweight/physiopathology ; Oxygen Consumption/physiology ; Weight Loss/physiology
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Grant Information :
P30-AG-028747 United States AG NIA NIH HHS; K23 AG-040775 United States AG NIA NIH HHS; R01-AG-019310 United States AG NIA NIH HHS; P30 AG028747 United States AG NIA NIH HHS; R01 AG019310 United States AG NIA NIH HHS; P30 DK072488 United States DK NIDDK NIH HHS; K23 AG040775 United States AG NIA NIH HHS; P30-DK-072488 United States DK NIDDK NIH HHS
Molecular Sequence :
ClinicalTrials.gov NCT00882141; NCT00971594
Substance Nomenclature :
0 (Blood Glucose)
0 (Insulin)
Entry Date(s) :
Date Created: 20140306 Date Completed: 20150429 Latest Revision: 20181202
Update Code :
20201218
PubMed Central ID :
PMC3994928
DOI :
10.2337/dc13-2358
PMID :
24595633
Czasopismo naukowe
Objective: Transcapillary transport of insulin is one determinant of glucose uptake by skeletal muscle; thus, a reduction in capillary density (CD) may worsen insulin sensitivity. Skeletal muscle CD is lower in older adults with impaired glucose tolerance (IGT) compared with those with normal glucose tolerance and may be modifiable through aerobic exercise training and weight loss (AEX+WL). We tested the hypothesis that 6-month AEX+WL would increase CD to improve insulin sensitivity and glucose tolerance in older adults with IGT.
Research Design and Methods: Sixteen sedentary, overweight-obese (BMI 27-35 kg/m2), older (63 ± 2 years) men and women with IGT underwent hyperinsulinemic-euglycemic clamps to measure insulin sensitivity, oral glucose tolerance tests, exercise and body composition testing, and vastus lateralis muscle biopsies to determine CD before and after 6-month AEX+WL.
Results: Insulin sensitivity (M) and 120-min postprandial glucose (G120) correlated with CD at baseline (r = 0.58 and r = -0.60, respectively, P < 0.05). AEX+WL increased maximal oxygen consumption (VO2max) 18% (P = 0.02) and reduced weight and fat mass 8% (P < 0.02). CD increased 15% (264 ± 11 vs. 304 ± 14 capillaries/mm(2), P = 0.01), M increased 21% (42.4 ± 4.0 vs. 51.4 ± 4.3 µmol/kg FFM/min, P < 0.05), and G120 decreased 16% (9.35 ± 0.5 vs. 7.85 ± 0.5 mmol/L, P = 0.008) after AEX+WL. Regression analyses showed that the AEX+WL-induced increase in CD independently predicted the increase in M (r = 0.74, P < 0.01) as well as the decrease in G120 (r = -0.55, P < 0.05).
Conclusions: Six-month AEX+WL increases skeletal muscle CD in older adults with IGT. This represents one mechanism by which AEX+WL improves insulin sensitivity in older adults with IGT.

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