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Tytuł pozycji:

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.

Tytuł:
TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.
Autorzy:
Ishikawa H; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Ide T
Yagi T
Jiang X
Hirono M
Sasaki H
Yanagisawa H
Wemmer KA
Stainier DY
Qin H
Kamiya R
Marshall WF
Źródło:
ELife [Elife] 2014 Jan 01; Vol. 3, pp. e01566. Date of Electronic Publication: 2014 Jan 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
Język:
English
Imprint Name(s):
Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
MeSH Terms:
Cell Movement*
Algal Proteins/*metabolism
Carrier Proteins/*metabolism
Chlamydomonas reinhardtii/*metabolism
Cilia/*metabolism
Flagella/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Plant Proteins/*metabolism
Zebrafish Proteins/*metabolism
Algal Proteins/genetics ; Animals ; Carrier Proteins/genetics ; Cell Line ; Chlamydomonas reinhardtii/genetics ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Genotype ; Intracellular Signaling Peptides and Proteins/genetics ; Mice ; Mutation ; Phenotype ; Plant Proteins/genetics ; Protein Transport ; Transfection ; Zebrafish ; Zebrafish Proteins/genetics
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Grant Information:
R01 GM097017 United States GM NIGMS NIH HHS; GM077004 United States GM NIGMS NIH HHS; GM097017 United States GM NIGMS NIH HHS; HL54737 United States HL NHLBI NIH HHS; R01 GM077004 United States GM NIGMS NIH HHS; R01 HL054737 United States HL NHLBI NIH HHS
Contributed Indexing:
Keywords: Chlamydomonas; axoneme; dynein; flagella
Note: Original DateCompleted: 20140305
Substance Nomenclature:
0 (Algal Proteins)
0 (Carrier Proteins)
0 (Intracellular Signaling Peptides and Proteins)
0 (Plant Proteins)
0 (Ttc26 protein, mouse)
0 (Ttc26 protein, zebrafish)
0 (Zebrafish Proteins)
Entry Date(s):
Date Created: 20140306 Date Completed: 20151124 Latest Revision: 20230701
Update Code:
20240104
PubMed Central ID:
PMC3936282
DOI:
10.7554/eLife.01566
PMID:
24596149
Czasopismo naukowe
Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear. To help address this issue, we focused on a putative IFT protein TTC26/DYF13. Using live imaging and biochemical approaches we show that TTC26/DYF13 is an IFT complex B protein in mammalian cells and Chlamydomonas reinhardtii. Knockdown of TTC26/DYF13 in zebrafish embryos or mutation of TTC26/DYF13 in C. reinhardtii, produced short cilia with abnormal motility. Surprisingly, IFT particle assembly and speed were normal in dyf13 mutant flagella, unlike in other IFT complex B mutants. Proteomic and biochemical analyses indicated a particular set of proteins involved in motility was specifically depleted in the dyf13 mutant. These results support the concept that different IFT proteins are responsible for different cargo subsets, providing a possible explanation for the complexity of the IFT machinery. DOI: http://dx.doi.org/10.7554/eLife.01566.001.
Comment in: Elife. 2014;3:e02531. (PMID: 24642415)
Erratum in: Elife. 2014 Apr 01;3:e02897. (PMID: 24692455)

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