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Tytuł:
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Prostaglandin E₂ receptor EP2 mediates Snail expression in hepatocellular carcinoma cells.
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Autorzy:
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Cheng SY; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zhang H; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zhang M; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Xia SK; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Bai XM; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zhang L; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Ma J; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Rong R; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Wang YP; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Du MZ; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Wang J; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Chen M; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Shi F; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Yang QY; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Leng J; Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
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Źródło:
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Oncology reports [Oncol Rep] 2014 May; Vol. 31 (5), pp. 2099-106. Date of Electronic Publication: 2014 Mar 11.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: <2003->: Athens : D.A. Spandidos
Original Publication: [Athens, Greece] : National Hellenic Research Foundation, 1994-
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MeSH Terms:
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Carcinoma, Hepatocellular/*pathology
Dinoprostone/*metabolism
Liver Neoplasms/*pathology
Receptors, Prostaglandin E, EP2 Subtype/*metabolism
Transcription Factors/*biosynthesis
Carcinoma, Hepatocellular/genetics ; Cyclooxygenase 2 ; Epithelial-Mesenchymal Transition ; ErbB Receptors/biosynthesis ; Humans ; Liver Neoplasms/genetics ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Proto-Oncogene Proteins c-akt/biosynthesis ; Signal Transduction ; Snail Family Transcription Factors ; TOR Serine-Threonine Kinases/biosynthesis ; Up-Regulation ; src-Family Kinases/biosynthesis
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Substance Nomenclature:
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0 (Receptors, Prostaglandin E, EP2 Subtype)
0 (Snail Family Transcription Factors)
0 (Transcription Factors)
EC 1.14.99.1 (Cyclooxygenase 2)
EC 1.14.99.1 (PTGS2 protein, human)
EC 2.7.1.1 (MTOR protein, human)
EC 2.7.10.1 (EGFR protein, human)
EC 2.7.10.1 (ErbB Receptors)
EC 2.7.10.2 (src-Family Kinases)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
EC 2.7.11.1 (TOR Serine-Threonine Kinases)
K7Q1JQR04M (Dinoprostone)
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Entry Date(s):
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Date Created: 20140315 Date Completed: 20150112 Latest Revision: 20211203
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Update Code:
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20240104
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DOI:
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10.3892/or.2014.3074
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PMID:
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24626807
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Prostaglandin E2 (PGE2) has been shown to influence cell invasion and metastasis in several types of cancer, including hepatocellular carcinoma (HCC). however, the molecular mechanisms underlying it remain to be further elucidated. Snail, as one of key inducers of epithelial-mesenchymal transition (EMT), plays pivotal roles in HCC invasion and metastasis. The present study was designed to evaluate the possible signaling pathways through which PGE2 regulates Snail protein expression in HCC cell lines. PGE2 markedly enhanced Huh-7 cell invasion and migration ability by upregulating the expression level of Snail protein, and EP2 receptor played an important role in this process. Src, EGFR, Akt and mTOR were all activated and involved in the regulation of snail protein expression. Our findings suggest that PGE2 could upregulate the expression level of Snail protein through the EP2/Src/EGFR/Akt/mTOR pathway in Huh-7 cells, which promotes HCC cell invasion and migration.
