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Tytuł pozycji:

In vitro exposure of DE-71, a penta-PBDE mixture, on immune endpoints in bottlenose dolphins (Tursiops truncatus) and B6C3F1 mice.

Tytuł:
In vitro exposure of DE-71, a penta-PBDE mixture, on immune endpoints in bottlenose dolphins (Tursiops truncatus) and B6C3F1 mice.
Autorzy:
Wirth JR; Graduate Program in Marine Biology, College of Charleston, 205 Fort Johnson Road, Charleston, SC, 29412, USA.
Peden-Adams MM
White ND
Bossart GD
Fair PA
Źródło:
Journal of applied toxicology : JAT [J Appl Toxicol] 2015 Feb; Vol. 35 (2), pp. 191-8. Date of Electronic Publication: 2014 Apr 07.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Publication: : Chichester : John Wiley And Sons
Original Publication: [Philadelphia, Pa. : Heyden & Son, c1981-
MeSH Terms:
Bottle-Nosed Dolphin/*immunology
Halogenated Diphenyl Ethers/*toxicity
Immunity, Cellular/*drug effects
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Female ; Killer Cells, Natural/drug effects ; Leukocytes/drug effects ; Lymphocyte Activation/drug effects ; Lymphocytes/drug effects ; Male ; Mice ; Spleen/cytology ; Spleen/drug effects
Contributed Indexing:
Keywords: DE-71; Tursiops truncatus; dolphins; immunology; in vitro; lymphocyte proliferation; mouse splenocytes; natural killer (NK) cell activity; polybrominated diphenyl ethers (PBDE)
Substance Nomenclature:
0 (Halogenated Diphenyl Ethers)
7REL09ZX35 (pentabromodiphenyl ether)
Entry Date(s):
Date Created: 20140408 Date Completed: 20150828 Latest Revision: 20161125
Update Code:
20240104
DOI:
10.1002/jat.3008
PMID:
24706408
Czasopismo naukowe
Polybrominated diphenyl ethers (PBDEs) are an emerging contaminant of concern with low level exposures demonstrating toxicity in laboratory animals and wildlife, although immunotoxicity studies have been limited. Bottlenose dolphin peripheral blood leukocytes (PBLs) and mouse splenocytes were exposed to environmentally relevant DE-71 (a penta-PBDE mixture) concentrations (0-50 µg ml(-1) ) in vitro. Natural killer (NK) cell activity and lymphocyte (B and T cell) proliferation were evaluated using the parallelogram approach for risk assessment. This study aimed to substantiate results from field studies with dolphins, assess the sensitivities between the mouse model and dolphins, and to evaluate risk using the parallelogram approach. In mouse cells, NK cell activity increased at in vitro doses 0.05, 0.5 and 25 µg DE-71 ml(-1) , whereas proliferation was not modulated. In dolphin cells, NK cell activity and lymphocyte proliferation was not altered after in vitro exposure. In vitro exposure of dolphin PBLs to DE-71 showed similar results to correlative field studies; NK cell activity in mice was more sensitive to in vitro exposure than dolphins, and the parallelogram approach showed correlation with all three endpoints to predict risk in bottlenose dolphins.
(Copyright © 2014 John Wiley & Sons, Ltd.)

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