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Tytuł pozycji:

Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.

Tytuł:
Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.
Autorzy:
Rice AD; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Adams MM; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Lindsey SF; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Swetnam DM; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Manning BR; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Smith AJ; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Burrage AM; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Wallace G; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
MacNeill AL; Departments of Microbiology, Immunology and Pathology, CVMBS, Colorado State University, Ft. Collins, Colorado, USA.
Moyer RW; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA .
Źródło:
Journal of virology [J Virol] 2014 Jul; Vol. 88 (14), pp. 7753-63. Date of Electronic Publication: 2014 Apr 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Język:
English
Imprint Name(s):
Publication: Washington Dc : American Society For Microbiology
Original Publication: Baltimore, American Society for Microbiology.
MeSH Terms:
Smallpox/*prevention & control
Smallpox Vaccine/*immunology
Vaccination/*methods
Vaccinia virus/*immunology
Administration, Cutaneous ; Animals ; Female ; Rabbits ; Smallpox Vaccine/administration & dosage
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Grant Information:
R01 AI015722 United States AI NIAID NIH HHS; R56 AI015722 United States AI NIAID NIH HHS; U54 AI057157 United States AI NIAID NIH HHS; AI 15722 United States AI NIAID NIH HHS
Substance Nomenclature:
0 (Smallpox Vaccine)
Entry Date(s):
Date Created: 20140425 Date Completed: 20140822 Latest Revision: 20211021
Update Code:
20240104
PubMed Central ID:
PMC4097768
DOI:
10.1128/JVI.00185-14
PMID:
24760885
Czasopismo naukowe
The process of vaccination introduced by Jenner generated immunity against smallpox and ultimately led to the eradication of the disease. Procedurally, in modern times, the virus is introduced into patients via a process called scarification, performed with a bifurcated needle containing a small amount of virus. What was unappreciated was the role that scarification itself plays in generating protective immunity. In rabbits, protection from lethal disease is induced by intradermal injection of vaccinia virus, whereas a protective response occurs within the first 2 min after scarification with or without virus, suggesting that the scarification process itself is a major contributor to immunoprotection. importance: These results show the importance of local nonspecific immunity in controlling poxvirus infections and indicate that the process of scarification should be critically considered during the development of vaccination protocols for other infectious agents.
(Copyright © 2014, American Society for Microbiology. All Rights Reserved.)

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