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Tytuł pozycji:

Determinants of disability in multiple sclerosis: an immunological and MRI study.

Tytuł:
Determinants of disability in multiple sclerosis: an immunological and MRI study.
Autorzy:
Tortorella P; Unit of Motor Neurorehabilitation, Multiple Sclerosis Center, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Laganà MM; MR Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Saresella M; Immunology Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Tavazzi E; Unit of Motor Neurorehabilitation, Multiple Sclerosis Center, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Preti MG; MR Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy ; Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci, 20133 Milan, Italy.
Ricci C; Epidemiology and Statistics Unit, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy ; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Baglio F; MR Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Marventano I; Immunology Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Piancone F; Immunology Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Baselli G; Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci, 20133 Milan, Italy.
Cecconi P; MR Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Caputo D; Unit of Motor Neurorehabilitation, Multiple Sclerosis Center, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Clerici M; Immunology Research Laboratory, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Rovaris M; Unit of Motor Neurorehabilitation, Multiple Sclerosis Center, Fondazione Don Gnocchi, IRCCS Santa Maria Nascente, Via Capecelatro 66, 20148 Milan, Italy.
Źródło:
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 875768. Date of Electronic Publication: 2014 Apr 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: New York, NY : Hindawi Pub. Co.
MeSH Terms:
Disability Evaluation*
Magnetic Resonance Imaging*
Multiple Sclerosis/*diagnosis
Multiple Sclerosis/*immunology
Adult ; Case-Control Studies ; Cytokines/biosynthesis ; Demography ; Diffusion Magnetic Resonance Imaging ; Female ; Humans ; Male ; Middle Aged ; Phenotype
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Substance Nomenclature:
0 (Cytokines)
Entry Date(s):
Date Created: 20140513 Date Completed: 20141228 Latest Revision: 20211021
Update Code:
20240104
PubMed Central ID:
PMC4000958
DOI:
10.1155/2014/875768
PMID:
24818159
Czasopismo naukowe
Multiple sclerosis (MS) is characterized by a wide interpatient clinical variability and available biomarkers of disease severity still have suboptimal reliability. We aimed to assess immunological and MRI-derived measures of brain tissue damage in patients with different motor impairment degrees, for in vivo investigating the pathogenesis of MS-related disability. Twenty-two benign (B), 26 secondary progressive (SP), and 11 early, nondisabled relapsing-remitting (RR) MS patients and 37 healthy controls (HC) underwent conventional and diffusion tensor brain MRI and, as regards MS patients, immunophenotypic and functional analysis of stimulated peripheral blood mononuclear cells (PBMC). Corticospinal tract (CST) fractional anisotropy and grey matter volume were lower and CST diffusivity was higher in SPMS compared to RRMS and BMS patients. CD14+IL6+ and CD4+IL25+ cell percentages were higher in BMS than in SPMS patients. A multivariable model having EDSS as the dependent variable retained the following independent predictors: grey matter volume, CD14+IL6+ and CD4+IL25+ cell percentages. In patients without motor impairment after long-lasting MS, the grey matter and CST damage degree seem to remain as low as in the earlier disease stages and an immunological pattern suggestive of balanced pro- and anti-inflammatory activity is observed. MRI-derived and immunological measures might be used as complementary biomarkers of MS severity.

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