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Tytuł pozycji:

Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein.

Tytuł :
Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein.
Autorzy :
Jaworski E; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Narayanan A; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Van Duyne R; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, the Department of Microbiology, Immunology, and Tropical Medicine and.
Shabbeer-Meyering S; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Iordanskiy S; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, the Department of Microbiology, Immunology, and Tropical Medicine and.
Saifuddin M; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Das R; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Afonso PV; the Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, F-75015 Paris, France, CNRS, UMR3569, F-75015 Paris, France, and.
Sampey GC; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Chung M; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Popratiloff A; the Department of Chemistry, George Washington University, Washington, D. C. 20037.
Shrestha B; Center for Microscopy and Image Analysis, George Washington University Medical Center, Washington, D. C. 20037.
Sehgal M; the Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902.
Jain P; the Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902.
Vertes A; Center for Microscopy and Image Analysis, George Washington University Medical Center, Washington, D. C. 20037.
Mahieux R; the Equipe Oncogenèse Rétrovirale, Equipe labelisée 'Ligue Nationale Contre le Cancer,' International Center for Research in Infectiology, INSERM U1111-CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon 69364 Cedex 07, France.
Kashanchi F; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2014 Aug 08; Vol. 289 (32), pp. 22284-305. Date of Electronic Publication: 2014 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język :
English
Imprint Name(s) :
Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
MeSH Terms :
Gene Products, tax/*metabolism
Human T-lymphotropic virus 1/*pathogenicity
Human T-lymphotropic virus 1/*physiology
Cell Line ; Cell Survival ; Dendritic Cells/immunology ; Dendritic Cells/physiology ; Dendritic Cells/virology ; Exosomes/metabolism ; Exosomes/virology ; Gene Products, tax/immunology ; HTLV-I Infections/etiology ; HTLV-I Infections/physiopathology ; HTLV-I Infections/virology ; Host-Pathogen Interactions ; Human T-lymphotropic virus 1/immunology ; Humans ; Virulence ; fas Receptor/antagonists & inhibitors
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Grant Information :
R01 CA054559 United States CA NCI NIH HHS; R21 AI074410 United States AI NIAID NIH HHS; AI078859 United States AI NIAID NIH HHS; AI043894 United States AI NIAID NIH HHS; AI074410 United States AI NIAID NIH HHS; R21 AI078859 United States AI NIAID NIH HHS; R01 AI043894 United States AI NIAID NIH HHS; R01 AI077414 United States AI NIAID NIH HHS
Contributed Indexing :
Keywords: Biomarker; Cytokine Induction; Exosome; HTLV-1 Infection; Leukemia; Oncogene; Tax Protein; Transactivation
Substance Nomenclature :
0 (Gene Products, tax)
0 (fas Receptor)
0 (tax protein, Human T-lymphotrophic virus 1)
Entry Date(s) :
Date Created: 20140619 Date Completed: 20150219 Latest Revision: 20210205
Update Code :
20210210
PubMed Central ID :
PMC4139239
DOI :
10.1074/jbc.M114.549659
PMID :
24939845
Czasopismo naukowe
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. The HTLV-1 transactivator protein Tax controls many critical cellular pathways, including host cell DNA damage response mechanisms, cell cycle progression, and apoptosis. Extracellular vesicles called exosomes play critical roles during pathogenic viral infections as delivery vehicles for host and viral components, including proteins, mRNA, and microRNA. We hypothesized that exosomes derived from HTLV-1-infected cells contain unique host and viral proteins that may contribute to HTLV-1-induced pathogenesis. We found exosomes derived from infected cells to contain Tax protein and proinflammatory mediators as well as viral mRNA transcripts, including Tax, HBZ, and Env. Furthermore, we observed that exosomes released from HTLV-1-infected Tax-expressing cells contributed to enhanced survival of exosome-recipient cells when treated with Fas antibody. This survival was cFLIP-dependent, with Tax showing induction of NF-κB in exosome-recipient cells. Finally, IL-2-dependent CTLL-2 cells that received Tax-containing exosomes were protected from apoptosis through activation of AKT. Similar experiments with primary cultures showed protection and survival of peripheral blood mononuclear cells even in the absence of phytohemagglutinin/IL-2. Surviving cells contained more phosphorylated Rb, consistent with the role of Tax in regulation of the cell cycle. Collectively, these results suggest that exosomes may play an important role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells.
(© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.)

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