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Tytuł pozycji:

Initially localized synovial sarcoma in adults: a retrospective single-center analysis of 26 patients registered at the Department of Oncology, University of Vienna between 2004 and 2013.

Tytuł :
Initially localized synovial sarcoma in adults: a retrospective single-center analysis of 26 patients registered at the Department of Oncology, University of Vienna between 2004 and 2013.
Autorzy :
Lamm W; Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Schur S
Köstler WJ
Amann G
Pokrajac B
Funovics P
Panotopoulos J
Brodowicz T
Pokaż więcej
Źródło :
Oncology [Oncology] 2014; Vol. 87 (1), pp. 48-57. Date of Electronic Publication: 2014 Jun 25.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Basel, New York, Karger.
MeSH Terms :
Neoplasm Recurrence, Local/*prevention & control
Sarcoma, Synovial/*therapy
Soft Tissue Neoplasms/*therapy
Adult ; Aged ; Aged, 80 and over ; Austria ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Prognosis ; Retrospective Studies ; Sarcoma, Synovial/mortality ; Soft Tissue Neoplasms/mortality ; Treatment Outcome ; Young Adult
Entry Date(s) :
Date Created: 20140628 Date Completed: 20140903 Latest Revision: 20140711
Update Code :
20210210
DOI :
10.1159/000363185
PMID :
24969357
Czasopismo naukowe
Background: Synovial sarcoma is a rare subgroup of all soft-tissue sarcomas. The aim of this retrospective single-center analysis was to investigate the outcome of patients with initially localized disease.
Patients and Methods: Twenty-six patients were enrolled in this retrospective single-center analysis. Baseline characteristics, treatment and outcome were evaluated.
Results: In 13 patients (50%), the tumor was located in the lower extremity and in 4 patients (15%) in the upper extremity. Surgical resection was done in all but 2 patients (92%). Re-resection was done in 7 patients (27%). Fourteen patients (54%) received adjuvant chemotherapy. After a median follow-up of 23.3 months (range: 2.6-150.3), median disease-free survival was not reached at the time of analysis. Eight patients (31%) relapsed after initial therapy. Surgery was done in 2 patients, amputation in 1 patient, palliative chemotherapy was administered in 3 and radiation therapy in 2 patients. Median overall survival (OS) for all patients was not reached at the time of analysis. The estimated 5-year OS rate was 62%.
Conclusion: Patients with initially localized synovial sarcoma who were included in this retrospective single-center analysis have an estimated 5-year OS rate of 62%.
(© 2014 S. Karger AG, Basel.)

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