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Tytuł pozycji:

Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice.

Tytuł :
Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice.
Autorzy :
Dankmeyer JL; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Fast RL; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Cote CK; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Worsham PL; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Fritz D; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Fisher D; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Kern SJ; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
Merkel T; Center of Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA.
Kirschning CJ; Institute of Medical Microbiology, University Duisburg-Essen, Essen, Germany.
Amemiya K; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21703, USA.
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Źródło :
Journal of immunology research [J Immunol Res] 2014; Vol. 2014, pp. 341820. Date of Electronic Publication: 2014 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Cairo, Egypt : Hindawi Publishing Corporation, [2014]-
MeSH Terms :
Myeloid Differentiation Factor 88/*metabolism
Plague/*immunology
Plague/*metabolism
Plague Vaccine/*immunology
Yersinia pestis/*immunology
Animals ; Antibodies, Bacterial/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Mice ; Mice, Knockout ; Myeloid Differentiation Factor 88/deficiency ; Myeloid Differentiation Factor 88/genetics ; Plague/genetics ; Plague/mortality ; Plague/prevention & control ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism ; Spleen/pathology ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
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Substance Nomenclature :
0 (Antibodies, Bacterial)
0 (Cytokines)
0 (Myeloid Differentiation Factor 88)
0 (Plague Vaccine)
0 (Toll-Like Receptor 4)
Entry Date(s) :
Date Created: 20140705 Date Completed: 20150223 Latest Revision: 20181113
Update Code :
20210210
PubMed Central ID :
PMC4065692
DOI :
10.1155/2014/341820
PMID :
24995344
Czasopismo naukowe
The current candidate vaccine against Yersinia pestis infection consists of two subunit proteins: the capsule protein or F1 protein and the low calcium response V protein or V-antigen. Little is known of the recognition of the vaccine by the host's innate immune system and how it affects the acquired immune response to the vaccine. Thus, we vaccinated Toll-like receptor (Tlr) 2, 4, and 2/4-double deficient, as well as signal adaptor protein Myd88-deficient mice. We found that Tlr4 and Myd88 appeared to be required for an optimal immune response to the F1-V vaccine but not Tlr2 when compared to wild-type mice. However, there was a difference between the requirement for Tlr4 and MyD88 in vaccinated animals. When F1-V vaccinated Tlr4 mutant (lipopolysaccharide tolerant) and Myd88-deficient mice were challenged by aerosol with Y. pestis CO92, all but one Tlr4 mutant mice survived the challenge, but no vaccinated Myd88-deficient mice survived the challenge. Spleens from these latter nonsurviving mice showed that Y. pestis was not cleared from the infected mice. Our results suggest that MyD88 appears to be important for both an optimal immune response to F1-V and in protection against a lethal challenge of Y. pestis CO92 in F1-V vaccinated mice.

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