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Tytuł pozycji:

Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease.

Tytuł :
Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease.
Autorzy :
Vermeiren Y; Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Van Dam D; Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Aerts T; Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Engelborghs S; Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.
De Deyn PP; Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, the Netherlands; Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address: .
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2014 Dec; Vol. 35 (12), pp. 2691-2700. Date of Electronic Publication: 2014 Jun 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
MeSH Terms :
Aggression*
Depression*
Alzheimer Disease/*metabolism
Alzheimer Disease/*psychology
Brain/*metabolism
Neurotransmitter Agents/*metabolism
Aged ; Aged, 80 and over ; Chromatography, High Pressure Liquid ; Dopamine/metabolism ; Epinephrine/metabolism ; Female ; Homovanillic Acid/metabolism ; Humans ; Hydroxyindoleacetic Acid/metabolism ; Male ; Methoxyhydroxyphenylglycol/metabolism ; Serotonin/metabolism
Contributed Indexing :
Keywords: Aggression; Alzheimer's disease; Biogenic amines and metabolites; Brain tissue; Dementia; Depression; Neurochemistry; Neuropsychiatric symptoms (NPS)
Substance Nomenclature :
0 (Neurotransmitter Agents)
333DO1RDJY (Serotonin)
534-82-7 (Methoxyhydroxyphenylglycol)
54-16-0 (Hydroxyindoleacetic Acid)
VTD58H1Z2X (Dopamine)
X77S6GMS36 (Homovanillic Acid)
YKH834O4BH (Epinephrine)
Entry Date(s) :
Date Created: 20140707 Date Completed: 20151109 Latest Revision: 20170915
Update Code :
20210210
DOI :
10.1016/j.neurobiolaging.2014.05.031
PMID :
24997673
Czasopismo naukowe
Depression and aggression in Alzheimer's disease (AD) are 2 of the most severe and prominent neuropsychiatric symptoms (NPS). Altered monoaminergic neurotransmitter system functioning has been implicated in both NPS, although their neurochemical etiology remains to be elucidated. Left frozen hemispheres of 40 neuropathologically confirmed AD patients were regionally dissected. Dichotomization based on depression and aggression scores resulted in depressed/nondepressed (AD + D/AD - D) and aggressive/nonaggressive (AD + Agr/AD - Agr) groups. Concentrations of dopamine, serotonin (5-HT), (nor)epinephrine ((N)E), and respective metabolites were determined using reversed-phase high-performance liquid chromatography. Significantly lower 3-methoxy-4-hydroxyphenylglycol (MHPG) and higher homovanillic acid levels were observed in Brodmann area (BA) 9 and 10 of AD + D compared with AD - D. In AD + Agr, 5-hydroxy-3-indoleacetic acid (5-HIAA) levels in BA9, 5-HIAA to 5-HT ratios in BA11, and MHPG, NE, and 5-HIAA levels in the hippocampus were significantly decreased compared with AD - Agr. These findings indicate that brain region-specific altered monoamines and metabolites may contribute to the occurrence of depression and aggression in AD.
(Copyright © 2014 Elsevier Inc. All rights reserved.)

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