Molecular and cellular basis of scleroderma.

Szczegóły
Abstrakt

Tytuł:: Molecular and cellular basis of scleroderma.
Autorzy:: Eckes B; Department of Dermatology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Moinzadeh P
Sengle G
Hunzelmann N
Krieg T
Źródło:: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2014 Sep; Vol. 92 (9), pp. 913-24. Date of Electronic Publication: 2014 Jul 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: Berlin : Springer International
Original Publication: Berlin : Springer, c1994-
MeSH Terms:: Extracellular Matrix/*pathology
Fibroblasts/*pathology
Scleroderma, Systemic/*pathology
Skin/*pathology
Animals ; Extracellular Matrix/genetics ; Extracellular Matrix/immunology ; Fibroblasts/immunology ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Inflammation/complications ; Inflammation/immunology ; Inflammation/pathology ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/immunology ; Signal Transduction ; Skin/blood supply ; Skin/immunology ; Skin/metabolism
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Entry Date(s):: Date Created: 20140718 Date Completed: 20150406 Latest Revision: 20211021
Update Code:: 20240104
DOI:: 10.1007/s00109-014-1190-x
PMID:: 25030650
: Czasopismo naukowe

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Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

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