-
Tytuł:
-
Minocycline alleviates behavioral deficits and inhibits microglial activation in the offspring of pregnant mice after administration of polyriboinosinic-polyribocytidilic acid.
-
Autorzy:
-
Zhu F; Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
Zheng Y; Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China; Department of General Psychiatry, Brain Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical College, Guangdong, Guangzhou 510370, China.
Liu Y; Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
Zhang X; Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
Zhao J; Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China. Electronic address: .
-
Źródło:
-
Psychiatry research [Psychiatry Res] 2014 Nov 30; Vol. 219 (3), pp. 680-6. Date of Electronic Publication: 2014 Jul 03.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
-
MeSH Terms:
-
Anti-Bacterial Agents/*pharmacology
Behavior, Animal/*drug effects
Brain/*drug effects
Microglia/*drug effects
Minocycline/*pharmacology
Poly I-C/*administration & dosage
Animals ; Animals, Newborn ; Cerebral Cortex/drug effects ; Disease Models, Animal ; Female ; Hippocampus/drug effects ; Hippocampus/pathology ; Humans ; Injections, Intraperitoneal ; Male ; Mice ; Poly I-C/pharmacology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prepulse Inhibition/drug effects ; Schizophrenia/pathology
-
Contributed Indexing:
-
Keywords: Microglia; Minocycline; Poly I:C; Schizophrenia
-
Substance Nomenclature:
-
0 (Anti-Bacterial Agents)
FYY3R43WGO (Minocycline)
O84C90HH2L (Poly I-C)
-
Entry Date(s):
-
Date Created: 20140722 Date Completed: 20150608 Latest Revision: 20220316
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.psychres.2014.06.046
-
PMID:
-
25042426
-
Epidemiological studies have indicated that maternal infection during pregnancy may lead to a higher incidence of schizophrenia in the offspring. Activation of microglia is a key event in the reaction of the cerebral immune system to pathological changes. It can be hypothesized that microglia contribute to the neuropathology of schizophrenia. In this study, at embryonic day (ED) 9 pregnant mice were treated with intraperitoneal injection of polyriboinosinic-polyribocytidilic acid (Poly I:C) at a single dose of 20 mg/kg. At postnatal day 42, descendants were treated with minocycline (40 mg/kg) or saline for consecutive 14 days. Behavioral changes (locomotor activity, social interaction, and prepulse inhibition) were examined and the number of microglia was assessed after the treatment. The adult offspring exposed to Poly I:C at ED 9 showed behavioral changes (hyperlocomotion, deficits in social interaction and prepulse inhibition) and significant microglial activation in these brain areas (hippocampus, thalamus, and cerebral cortex) compared to those in saline-injected group. Moreover, minocycline attenuated the behavioral deficits and inhibited the activated microglia. These findings suggest that maternal infection may contribute to microglial activation in the offspring. In addition, the effect of minocycline in this immune model may be related to the inhibition of microglial activation.
(Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
