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Tytuł pozycji:

Randomized controlled trial of asthma risk with paracetamol use in infancy--a feasibility study.

Tytuł :
Randomized controlled trial of asthma risk with paracetamol use in infancy--a feasibility study.
Autorzy :
Riley J; Medical Research Institute of New Zealand, Wellington, New Zealand.
Braithwaite I
Shirtcliffe P
Caswell-Smith R
Hunt A
Bowden V
Power S
Stanley T
Crane J
Ingham T
Weatherall M
Mitchell EA
Beasley R
Pokaż więcej
Źródło :
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2015 Feb; Vol. 45 (2), pp. 448-56.
Typ publikacji :
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Oxford : Blackwell Scientific Publications, c1989-
MeSH Terms :
Acetaminophen/*adverse effects
Asthma/*epidemiology
Asthma/*etiology
Acetaminophen/administration & dosage ; Adult ; Age Factors ; Feasibility Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Patient Outcome Assessment ; Risk ; Surveys and Questionnaires
Contributed Indexing :
Keywords: acetaminophen; asthma; bronchiolitis; comparator arm; feasibility; infants; paracetamol
Substance Nomenclature :
362O9ITL9D (Acetaminophen)
Entry Date(s) :
Date Created: 20141011 Date Completed: 20150924 Latest Revision: 20151119
Update Code :
20210209
DOI :
10.1111/cea.12433
PMID :
25303337
Czasopismo naukowe
Background: There is non-experimental evidence that paracetamol (acetaminophen) use may increase the risk of developing asthma. However, numerous methodological issues need to be resolved before undertaking a randomized controlled trial to investigate this hypothesis.
Objective: To establish the feasibility of a randomized controlled trial of liberal paracetamol as usually given by parents/guardians vs. a comparator (restricted paracetamol in accordance with WHO guidelines, ibuprofen or placebo), and childhood asthma risk.
Methods: Questionnaires were completed by parents/guardians of infants admitted to Wellington Hospital with bronchiolitis to assess views about comparator treatments. Subsequently, infants of parents/guardians who provided informed consent were randomized to restricted or liberal paracetamol use for 3 months with paracetamol use recorded.
Results: Of 120 eligible participants, 72 (60%) parents/guardians completed the questionnaire. Ibuprofen, restricted paracetamol and placebo were acceptable to 42 (58%), 29 (40%) and 9 (12%) parents/guardians, respectively. 36 (30%) infants were randomized to restricted or liberal paracetamol. Paracetamol use was greater for the liberal vs. restricted group for reported [Hodges-Lehmann estimator of difference 0.94 mg/kg/day (95% CI 0.2-3.52), P = 0.02] and measured use [Hodges-Lehmann estimator of difference 2.11 mg/kg/day (95% CI 0.9-4.18), P = 0.004]. The median reported and measured use of paracetamol was 2.0-fold and 3.5-fold greater in the liberal vs. restricted group.
Conclusions and Clinical Relevance: Although separation in paracetamol dosing is likely to be achieved with a liberal vs. restricted paracetamol regime, ibuprofen is the preferred comparator treatment in the proposed RCT of paracetamol use and risk of asthma in childhood.
(© 2014 John Wiley & Sons Ltd.)
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