AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.

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Abstrakt

Tytuł:: AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.
Autorzy:: Guo J; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Chen X; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Xi R; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Chang Y; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Zhang X; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Zhang X; Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Źródło:: Journal of biomedical research [J Biomed Res] 2014 Sep; Vol. 28 (5), pp. 388-95. Date of Electronic Publication: 2014 Aug 12.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: [Nanjing] : Editorial Department of the Journals of Nanjing Medical University
Original Publication: Nanjing : Education Dept. of Jiangsu Province
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Contributed Indexing:: Keywords: AEG-1; glioma; immunohistochemistry; radioresistance
Entry Date(s):: Date Created: 20141022 Date Completed: 20141021 Latest Revision: 20211021
Update Code:: 20240104
PubMed Central ID:: PMC4197390
DOI:: 10.7555/JBR.28.20140015
PMID:: 25332711
: Czasopismo naukowe

Pełny tekst

Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

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