Caspases: therapeutic targets in neurologic disease.

Szczegóły
Abstrakt

Tytuł:: Caspases: therapeutic targets in neurologic disease.
Autorzy:: Troy CM; Department of Pathology and Cell Biology, Columbia University Medical Center, 650 W. 168th Street, New York, NY, 10032, USA, .
Jean YY
Źródło:: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2015 Jan; Vol. 12 (1), pp. 42-8.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
Język:: English
Imprint Name(s):: Publication: 2024- : [New York] : Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics
Original Publication: Orlando, FL : Elsevier, c2007-
MeSH Terms:: Alzheimer Disease/*enzymology
Caspases/*metabolism
Neurodegenerative Diseases/*pathology
Alzheimer Disease/pathology ; Animals ; Humans ; Neurodegenerative Diseases/enzymology
References:: Biochem Biophys Res Commun. 2000 Nov 2;277(3):655-9. (PMID: 11062009)
Neuron. 2006 Dec 21;52(6):1061-72. (PMID: 17178408)
Clin Anat. 1995;8(6):429-31. (PMID: 8713166)
JAMA. 1997 Oct 22-29;278(16):1363-71. (PMID: 9343469)
Neurobiol Dis. 2002 Nov;11(2):341-54. (PMID: 12505426)
J Cell Biol. 2009 Apr 20;185(2):291-303. (PMID: 19364921)
J Biol Chem. 2006 Feb 10;281(6):3254-60. (PMID: 16339151)
Brain. 2014 Jun;137(Pt 6):1656-75. (PMID: 24727569)
Methods Enzymol. 2014;544:161-78. (PMID: 24974290)
Mol Neurobiol. 1995 Feb;10(1):19-45. (PMID: 7598831)
Am J Pathol. 1999 Nov;155(5):1459-66. (PMID: 10550301)
Biochem J. 2012 Jun 15;444(3):591-9. (PMID: 22515271)
Nature. 1992 Apr 30;356(6372):768-74. (PMID: 1574116)
Am J Pathol. 2008 Nov;173(5):1488-95. (PMID: 18818379)
EMBO J. 2005 Oct 19;24(20):3532-42. (PMID: 16193064)
Cell. 1998 Aug 7;94(3):325-37. (PMID: 9708735)
Cell. 2010 Mar 19;140(6):821-32. (PMID: 20303873)
Nat Cell Biol. 2006 Jan;8(1):72-7. (PMID: 16362053)
J Neurosci Res. 2010 Jul;88(9):1926-33. (PMID: 20143425)
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10032-7. (PMID: 12888622)
J Biol Chem. 1999 Aug 13;274(33):23426-36. (PMID: 10438520)
Cell. 1993 Nov 19;75(4):641-52. (PMID: 8242740)
Cancer Lett. 2013 May 28;332(2):151-5. (PMID: 22781394)
Cell. 1993 Nov 19;75(4):653-60. (PMID: 8242741)
Leukemia. 2014 Jul;28(7):1414-22. (PMID: 24487414)
Mol Cell. 2008 Apr 25;30(2):123-35. (PMID: 18439892)
Cell. 2000 Jul 7;102(1):33-42. (PMID: 10929711)
J Neuropathol Exp Neurol. 2006 May;65(5):508-15. (PMID: 16772874)
Nat Immunol. 2008 Aug;9(8):857-65. (PMID: 18604209)
Trends Neurosci. 2012 Nov;35(11):700-9. (PMID: 22796265)
Nat Commun. 2013;4:1939. (PMID: 23748737)
J Biol Chem. 2009 Aug 14;284(33):21777-21781. (PMID: 19473994)
J Neurosci. 2000 Feb 15;20(4):1386-92. (PMID: 10662829)
J Neuroimmunol. 2013 Dec 15;265(1-2):91-5. (PMID: 24144834)
Mol Cell. 2009 Sep 24;35(6):830-40. (PMID: 19782032)
Cell Death Differ. 2008 Feb;15(2):322-31. (PMID: 17975551)
Nat Med. 2000 Apr;6(4):397-404. (PMID: 10742146)
Neurobiol Dis. 2001 Dec;8(6):1006-16. (PMID: 11741396)
Biochem J. 2013 Oct 1;455(1):15-25. (PMID: 23815625)
Neurosci Bull. 2012 Feb;28(1):14-24. (PMID: 22233886)
J Neurosci. 2001 Jul 15;21(14):5007-16. (PMID: 11438576)
Arch Neurol. 2003 Mar;60(3):369-76. (PMID: 12633148)
Cell. 2005 Oct 7;123(1):89-103. (PMID: 16213215)
Cell. 2010 May 28;141(5):859-71. (PMID: 20510932)
Nat Rev Immunol. 2010 Mar;10(3):210-5. (PMID: 20168318)
Neuron. 2014 Jul 2;83(1):11-26. (PMID: 24991952)
Apoptosis. 2009 Sep;14(9):1039-49. (PMID: 19575295)
Nature. 2000 Jan 6;403(6765):98-103. (PMID: 10638761)
Science. 2010 Jan 15;327(5963):296-300. (PMID: 20075245)
J Pharmacol Sci. 2007 May;104(1):46-55. (PMID: 17452809)
J Cell Biol. 2004 May 10;165(3):347-56. (PMID: 15123740)
Cell Death Differ. 2002 Apr;9(4):358-61. (PMID: 11965488)
Curr Opin Immunol. 2007 Dec;19(6):615-22. (PMID: 17977705)
Alzheimers Dement. 2011 Jan;7(1):e1-12. (PMID: 21322828)
J Neurosci Res. 2003 Sep 15;73(6):853-64. (PMID: 12949912)
Biochem J. 2007 Jul 1;405(1):11-9. (PMID: 17437405)
Nat Neurosci. 2006 Oct;9(10):1234-6. (PMID: 16980964)
J Neurosci. 2011 Jun 15;31(24):8894-904. (PMID: 21677173)
Proc Natl Acad Sci U S A. 1996 May 28;93(11):5635-40. (PMID: 8643629)
Prog Mol Biol Transl Sci. 2011;99:265-305. (PMID: 21238939)
EMBO Rep. 2006 Oct;7(10):988-94. (PMID: 17016456)
Neurochem Int. 2010 Jan;56(2):352-6. (PMID: 19931333)
Mol Neurobiol. 2013 Dec;48(3):875-82. (PMID: 23686772)
Nature. 2010 Apr 22;464(7292):1201-4. (PMID: 20357768)
J Biomed Biotechnol. 2011;2011:464701. (PMID: 21331357)
Brain Res. 2001 Apr 20;898(2):350-7. (PMID: 11306022)
Grant Information:: R01 NS035933 United States NS NINDS NIH HHS; R01 NS043089 United States NS NINDS NIH HHS; R01 NS081333 United States NS NINDS NIH HHS; R01NS081333 United States NS NINDS NIH HHS
Substance Nomenclature:: EC 3.4.22.- (Caspases)
Entry Date(s):: Date Created: 20141024 Date Completed: 20160119 Latest Revision: 20240204
Update Code:: 20240205
PubMed Central ID:: PMC4322071
DOI:: 10.1007/s13311-014-0307-9
PMID:: 25339539
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Specific therapies for neurologic diseases such as Alzheimer's disease provide the potential for better clinical outcomes. Expression of caspases in the brain is developmentally regulated, and dysregulated in neurologic disease, supporting that caspases may be therapeutic targets. The activity of caspases is carefully regulated via binding partners, cleavage, or endogenous inhibitors to prevent spontaneous activation, which could lead to aberrant cell death. This review serves as a brief examination of the current understanding of the regulation and function of caspases, and approaches to specifically target aberrant caspase activity. The use of proper tools to investigate individual caspases is addressed. Moreover, it summarizes the reports of various caspases in Alzheimer's disease studies. A better understanding of specific caspase pathways in heath and neurodegenerative disease is crucial for identifying specific targets for the development of therapeutic interventions.

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