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Tytuł pozycji:

Urinary calprotectin and posttransplant renal allograft injury.

Tytuł:
Urinary calprotectin and posttransplant renal allograft injury.
Autorzy:
Tepel M; Department of Nephrology, Odense University Hospital, and University of Southern Denmark, Institute of Molecular Medicine, Cardiovascular and Renal Research, Institute of Clinical Research, Odense, Denmark.
Borst C; Department of Nephrology, Odense University Hospital, and University of Southern Denmark, Institute of Molecular Medicine, Cardiovascular and Renal Research, Institute of Clinical Research, Odense, Denmark.
Bistrup C; Department of Nephrology, Odense University Hospital, and University of Southern Denmark, Institute of Molecular Medicine, Cardiovascular and Renal Research, Institute of Clinical Research, Odense, Denmark.
Marcussen N; Department of Pathology, Odense University Hospital, and University of Southern Denmark, Odense, Denmark.
Pagonas N; Department of Nephrology, Charité, Campus Benjamin Franklin, Berlin, Germany; Medizinische Klinik I, Univ.-Klinik Marienhospital Herne, Ruhr-University Bochum, Bochum, Germany.
Seibert FS; Department of Nephrology, Charité, Campus Benjamin Franklin, Berlin, Germany; Medizinische Klinik I, Univ.-Klinik Marienhospital Herne, Ruhr-University Bochum, Bochum, Germany.
Arndt R; Department of Nephrology, Charité, Campus Benjamin Franklin, Berlin, Germany.
Zidek W; Department of Nephrology, Charité, Campus Benjamin Franklin, Berlin, Germany.
Westhoff TH; Department of Nephrology, Charité, Campus Benjamin Franklin, Berlin, Germany; Medizinische Klinik I, Univ.-Klinik Marienhospital Herne, Ruhr-University Bochum, Bochum, Germany.
Źródło:
PloS one [PLoS One] 2014 Nov 17; Vol. 9 (11), pp. e113006. Date of Electronic Publication: 2014 Nov 17 (Print Publication: 2014).
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:
Allografts*
Kidney/*pathology
Kidney/*physiopathology
Leukocyte L1 Antigen Complex/*urine
Aged ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Patient Outcome Assessment ; Prognosis ; Prospective Studies ; ROC Curve ; Risk Factors ; Time Factors ; Tissue Donors ; Transplantation, Homologous
References:
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Substance Nomenclature:
0 (Leukocyte L1 Antigen Complex)
Entry Date(s):
Date Created: 20141118 Date Completed: 20150708 Latest Revision: 20181113
Update Code:
20240104
PubMed Central ID:
PMC4234472
DOI:
10.1371/journal.pone.0113006
PMID:
25402277
Czasopismo naukowe
Objective: Current methods do not predict the acute renal allograft injury immediately after kidney transplantation. We evaluated the diagnostic performance of urinary calprotectin for predicting immediate posttransplant allograft injury.
Methods: In a multicenter, prospective-cohort study of 144 incipient renal transplant recipients, we postoperatively measured urinary calprotectin using an enzyme-linked immunosorbent assay and estimated glomerular filtration rate (eGFR) after 4 weeks, 6 months, and 12 months.
Results: We observed a significant inverse association of urinary calprotectin concentrations and eGFR 4 weeks after transplantation (Spearman r =  -0.33; P<0.001). Compared to the lowest quartile, patients in the highest quartile of urinary calprotectin had an increased risk for an eGFR less than 30 mL/min/1.73 m(2) four weeks after transplantation (relative risk, 4.3; P<0.001; sensitivity, 0.92; 95% CI, 0.77 to 0.98; specificity, 0.48; 95% CI, 0.31 to 0.66). Higher urinary calprotectin concentrations predicted impaired kidney function 4 weeks after transplantation, as well as 6 months and 12 months after transplantation. When data were analyzed using the urinary calprotectin/creatinine-ratio similar results were obtained. Urinary calprotectin was superior to current use of absolute change of plasma creatinine to predict allograft function 12 months after transplantation. Urinary calprotectin predicted an increased risk both in transplants from living and deceased donors. Multivariate linear regression showed that higher urinary calprotectin concentrations and older donor age predicted lower eGFR four weeks, 6 months, and 12 months after transplantation.
Conclusions: Urinary calprotectin is an early, noninvasive predictor of immediate renal allograft injury after kidney transplantation.

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