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Tytuł pozycji:

Spatial map of human T cell compartmentalization and maintenance over decades of life.

Tytuł:
Spatial map of human T cell compartmentalization and maintenance over decades of life.
Autorzy:
Thome JJ; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Yudanin N; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Ohmura Y; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Kubota M; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Grinshpun B; Department of Systems Biology and Biomedical Informatics, and the JP Sulzberger Columbia Genome Center, Columbia University, New York, NY 10032, USA.
Sathaliyawala T; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Kato T; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Lerner H; The New York Organ Donor Network (NYODN), New York, NY 10001, USA.
Shen Y; Department of Systems Biology and Biomedical Informatics, and the JP Sulzberger Columbia Genome Center, Columbia University, New York, NY 10032, USA.
Farber DL; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: .
Źródło:
Cell [Cell] 2014 Nov 06; Vol. 159 (4), pp. 814-28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
MeSH Terms:
Aging/*immunology
T-Lymphocytes/*cytology
T-Lymphocytes/*immunology
Adolescent ; Adult ; Aged ; CD28 Antigens/metabolism ; Cell Differentiation ; Child ; Child, Preschool ; Humans ; Interleukin-7 Receptor alpha Subunit/metabolism ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Middle Aged ; Mucous Membrane/cytology ; Mucous Membrane/immunology ; Receptors, Antigen, T-Cell/chemistry ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/metabolism ; Tissue Donors ; Young Adult
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Grant Information:
S10 RR027050 United States RR NCRR NIH HHS; P01AI06697 United States AI NIAID NIH HHS; P01 AI106697 United States AI NIAID NIH HHS; F31AG047003 United States AG NIA NIH HHS; F31 AG047003 United States AG NIA NIH HHS; RC1 AI086164 United States AI NIAID NIH HHS
Substance Nomenclature:
0 (CD28 Antigens)
0 (Interleukin-7 Receptor alpha Subunit)
0 (Receptors, Antigen, T-Cell)
Entry Date(s):
Date Created: 20141124 Date Completed: 20150317 Latest Revision: 20210103
Update Code:
20240104
PubMed Central ID:
PMC4243051
DOI:
10.1016/j.cell.2014.10.026
PMID:
25417158
Czasopismo naukowe
Mechanisms for human memory T cell differentiation and maintenance have largely been inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid and mucosal sites. We present here a multidimensional, quantitative analysis of human T cell compartmentalization and maintenance over six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors. Our results reveal that the distribution and tissue residence of naive, central, and effector memory, and terminal effector subsets is contingent on both their differentiation state and tissue localization. Moreover, T cell homeostasis driven by cytokine or TCR-mediated signals is different in CD4+ or CD8+ T cell lineages, varies with their differentiation stage and tissue localization, and cannot be inferred from blood. Our data provide an unprecedented spatial and temporal map of human T cell compartmentalization and maintenance, supporting distinct pathways for human T cell fate determination and homeostasis.

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