Do we foresee new emerging drugs to treat malignant hyperthermia?

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Tytuł:: Do we foresee new emerging drugs to treat malignant hyperthermia?
Autorzy:: Just KS; Witten/Herdecke University, Hospital Cologne-Merheim, Cologne Medical Centre, Department of Anaesthesiology , Ostmerheimer Strasse 200, Cologne , Germany.
Gerbershagen MU
Grensemann J
Wappler F
Źródło:: Expert opinion on emerging drugs [Expert Opin Emerg Drugs] 2015 Jun; Vol. 20 (2), pp. 161-4. Date of Electronic Publication: 2015 Mar 04.
Typ publikacji:: Editorial
Język:: English
Imprint Name(s):: Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London, UK : Ashley Publications Ltd.
MeSH Terms:: Nanoparticles*
Dantrolene/*therapeutic use
Malignant Hyperthermia/*drug therapy
Anesthesia, Inhalation/adverse effects ; Dantrolene/administration & dosage ; Drug Approval ; Humans ; Malignant Hyperthermia/genetics ; Malignant Hyperthermia/mortality ; Neuromuscular Depolarizing Agents/adverse effects
Contributed Indexing:: Keywords: anesthesia; dantrolene; dantrolene sodium suspension; malignant hyperthermia; nanocrystalline suspension
Substance Nomenclature:: 0 (Neuromuscular Depolarizing Agents)
F64QU97QCR (Dantrolene)
Entry Date(s):: Date Created: 20150305 Date Completed: 20160108 Latest Revision: 20150524
Update Code:: 20240104
DOI:: 10.1517/14728214.2015.1018178
PMID:: 25736705
: Opinia redakcyjna

Malignant hyperthermia (MH) is a life-threatening genetic sensitivity of skeletal muscles to volatile anesthetics and depolarizing neuromuscular blocking drugs occurring during or after anesthesia. Mortality of MH has been significantly reduced by using the skeletal muscle relaxant dantrolene. However, pharmacological disadvantages are known. By approval of a nanocrystalline dantrolene sodium suspension (DSS), a new product enters the market. DSS is a promising substance, but clinical data are lacking up to now. Especially with regard to newer knowledge on MH and its associated clinical presentations, there might be an increasing interest on DSS.

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