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Tytuł:
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Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure.
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Autorzy:
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Zhao XF; Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Xu Y; Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China .
Zhu ZY; Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Gao CY; Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Shi YN; Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
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Źródło:
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Genetics and molecular research : GMR [Genet Mol Res] 2015 Apr 10; Vol. 14 (2), pp. 3010-7. Date of Electronic Publication: 2015 Apr 10.
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Typ publikacji:
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Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: [Ribeirao Preto, SP Brazil] : FUNPEC, 2002-
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MeSH Terms:
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Heart Failure, Systolic/*therapy
Mesenchymal Stem Cell Transplantation/*methods
Umbilical Cord/*cytology
Adult ; Aged ; Case-Control Studies ; Chronic Disease ; Female ; Heart Failure, Systolic/metabolism ; Heart Failure, Systolic/physiopathology ; Heart Function Tests ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/metabolism ; Peptide Fragments/metabolism ; Recovery of Function ; Young Adult
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Substance Nomenclature:
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0 (Peptide Fragments)
0 (pro-brain natriuretic peptide (1-76))
114471-18-0 (Natriuretic Peptide, Brain)
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Entry Date(s):
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Date Created: 20150513 Date Completed: 20160421 Latest Revision: 20150513
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Update Code:
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20240104
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DOI:
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10.4238/2015.April.10.11
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PMID:
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25966065
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The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. Fifty-nine hospitalized patients with heart failure were randomly divided into a treatment group (30 patients) and a control group (29 patients). The treatment group received treatment with medication as well as intracoronary transplantation of umbilical cord MSCs, and the control group, only medication. The cardiac structure, function change, and rehospitalization and mortality rates of the 2 groups were observed before and 1 and 6 months after treatment. One month after the transplantation of umbilical cord MSCs, the incidence of fatigue, chest tightness, and dyspnea was high in the treatment group. The 6-min walking distance of the treatment group was found to be significantly higher than that of the control group (P < 0.05); in addition, the NT-proBNP level, left ventricular ejection fraction, and mortality rate of the treatment group were statistically lower than those of the control group (P < 0.05). Readmission rates showed a downward trend, but the difference was not statistically significant (P > 0.05). Using umbilical cord MSCs in the treatment of congestive heart failure can help improve cardiac remodeling and cardiac function and reduce the mortality rate.
