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Tytuł pozycji:

Epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma.

Tytuł:
Epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma.
Autorzy:
Breyer J; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany. .
Gierth M; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Shalekenov S; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Aziz A; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.; Department of Urology, University of Hamburg, Hamburg, Germany.
Schäfer J; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Burger M; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Denzinger S; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Hofstädter F; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Giedl C; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Otto W; Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.
Źródło:
World journal of urology [World J Urol] 2016 May; Vol. 34 (5), pp. 709-16. Date of Electronic Publication: 2015 Sep 22.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: [Berlin ; New York] : Springer International, 1983-
MeSH Terms:
Epithelial-Mesenchymal Transition*
Cadherins/*analysis
Carcinoma, Transitional Cell/*chemistry
Carcinoma, Transitional Cell/*pathology
Inhibitor of Apoptosis Proteins/*analysis
Urinary Bladder Neoplasms/*chemistry
Urinary Bladder Neoplasms/*pathology
Aged ; Aged, 80 and over ; Antigens, CD ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Survivin
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Contributed Indexing:
Keywords: E-cadherin; EMT; Immunohistochemistry; Non-muscle-invasive bladder cancer; Stage pTa bladder cancer; Survivin
Substance Nomenclature:
0 (Antigens, CD)
0 (BIRC5 protein, human)
0 (CDH1 protein, human)
0 (Cadherins)
0 (Inhibitor of Apoptosis Proteins)
0 (Survivin)
Entry Date(s):
Date Created: 20150924 Date Completed: 20170418 Latest Revision: 20220331
Update Code:
20221216
DOI:
10.1007/s00345-015-1690-5
PMID:
26394624
Czasopismo naukowe
Purpose: To determine whether the immunohistochemical markers survivin and E-cadherin can predict progress at initially diagnosed Ta bladder cancer.
Methods: We retrospectively searched for every initially diagnosed pTa urothelial bladder carcinoma having been treated at our single-center hospital in Germany from January 1992 up to December 2004. Follow-up was recorded up to June 2010, with recurrence or progress being the endpoints. Immunohistochemical staining and analysis of survivin and E-cadherin of the TURB specimens were performed. Outcome dependency of progression and no progression with immunohistochemical staining was analyzed using uni- and multivariate regression analysis, Kaplan-Meier analysis and uni- and multivariate Cox regression analysis.
Results: Overall, 233 patients were included. Forty-two percent of those were tumor free in their follow-up TURBs, 46 % had at least one pTa recurrence and 12 % even showed progress to at least pT1 bladder cancer. Aberrant staining of E-cadherin was found within 71 % of patients with progression in contrast to only 40 % in cases without progression (p = 0.004). Of all progressed patients, 92 % showed overexpression of survivin in their initial pTa specimen compared to 61 % without progression (p = 0.001). Kaplan-Meier analysis revealed aberrant E-cadherin staining to be associated with worse progression-free survival (PFS) (p = 0.005) as well as overexpression of survivin (p = 0.003). In multivariate Cox regression analysis, strong E-cadherin staining was an independent prognosticator for better PFS (p = 0.033) and multifocality (p = 0.046) and tumor size over 3 cm (p = 0.042) were prognosticators for worse PFS.
Conclusion: Adding the immunohistochemical markers survivin and E-cadherin could help to identify patients at risk of developing a progressive disease in initial stage pTa bladder cancer.

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