Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA.

Szczegóły
Abstrakt

Tytuł:: Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA.
Autorzy:: Weng R; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Cohen SM; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark .
Źródło:: Development (Cambridge, England) [Development] 2015 Nov 01; Vol. 142 (21), pp. 3713-20. Date of Electronic Publication: 2015 Sep 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Cambridge Eng : Company Of Biologists Limited
Original Publication: [Cambridge] : Company of Biologists, [c1987-
MeSH Terms:: Drosophila/*cytology
Drosophila/*physiology
MicroRNAs/*metabolism
Animals ; Brain/cytology ; Brain/metabolism ; Cell Lineage ; Cell Proliferation ; DNA-Binding Proteins/metabolism ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/metabolism ; Larva/metabolism ; Nerve Tissue Proteins/metabolism ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism
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Contributed Indexing:: Keywords: Bantam; Brat; MicroRNA; Neural stem cell; Prospero
Substance Nomenclature:: 0 (DNA-Binding Proteins)
0 (Drosophila Proteins)
0 (MicroRNAs)
0 (Nerve Tissue Proteins)
0 (Nuclear Proteins)
0 (Transcription Factors)
0 (bantam microRNA, Drosophila)
0 (brat protein, Drosophila)
0 (pros protein, Drosophila)
Entry Date(s):: Date Created: 20150924 Date Completed: 20160307 Latest Revision: 20181113
Update Code:: 20240104
PubMed Central ID:: PMC4647215
DOI:: 10.1242/dev.127209
PMID:: 26395494
: Czasopismo naukowe

Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.
(© 2015. Published by The Company of Biologists Ltd.)

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