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Tytuł:
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Lipophilicity of PCBs and fatty acids determines their mobilisation from blubber of weaned northern elephant seal pups.
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Autorzy:
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Louis C; Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve, Belgium. Electronic address: .
Covaci A; Department of Pharmaceutical Sciences, Toxicological Center, Campus Drie Eiken, Universiteit Antwerpen, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Crocker DE; Department of Biology, Sonoma State University, 1801 East Cotati Ave, Rohnert Park, CA 94928, USA.
Debier C; Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve, Belgium.
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Źródło:
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The Science of the total environment [Sci Total Environ] 2016 Jan 15; Vol. 541, pp. 599-602. Date of Electronic Publication: 2015 Oct 03.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Adipose Tissue/*metabolism
Environmental Monitoring/*methods
Fatty Acids/*metabolism
Polychlorinated Biphenyls/*metabolism
Seals, Earless/*metabolism
Water Pollutants, Chemical/*metabolism
Animals
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Contributed Indexing:
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Keywords: Adipose tissue; Fatty acids; Lipolysis; Polychlorinated biphenyls
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Substance Nomenclature:
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0 (Fatty Acids)
0 (Water Pollutants, Chemical)
DFC2HB4I0K (Polychlorinated Biphenyls)
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Entry Date(s):
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Date Created: 20151007 Date Completed: 20160822 Latest Revision: 20170808
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Update Code:
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20240104
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DOI:
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10.1016/j.scitotenv.2015.09.094
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PMID:
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26439651
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Polychlorinated biphenyls (PCBs) exhibit lipophilic properties that lead to their bioaccumulation in adipose tissue. Following PCB exposition, northern elephant seals (Mirounga angustirostris) concentrate high amounts of these pollutants in their large adipose tissue stores. During lipolytic periods such as the post-weaning fast, fatty acids (FAs), which form triglycerides, and PCBs are both mobilised from adipose tissue. Our results showed that the degree of lipophilicity of FAs and PCBs impacted their release: the more lipophilic FAs and PCBs tended to be more conserved in blubber over the fast than the less lipophilic ones. This led to an enrichment of more lipophilic compounds within adipocytes with the progression of the fast. Life history patterns that include fasting may thus influence the profile of blubber lipids and contaminants.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
