Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Usefulness of selected laboratory markers in ulcerative colitis.

Tytuł :
Usefulness of selected laboratory markers in ulcerative colitis.
Autorzy :
Mańkowska-Wierzbicka D
Swora-Cwynar E
Poniedziałek B
Adamski Z
Dobrowolska A
Karczewski J
Pokaż więcej
Źródło :
European cytokine network [Eur Cytokine Netw] 2015 Apr-Jun; Vol. 26 (2), pp. 26-37.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Montrouge, France : John Libbey Eurotext Ltd.
MeSH Terms :
Biomarkers*
Colitis, Ulcerative/*diagnosis
Colitis, Ulcerative/*metabolism
Adult ; Colitis, Ulcerative/therapy ; Colonoscopy ; Cytokines/metabolism ; Female ; Humans ; Inflammation Mediators/metabolism ; Male ; Middle Aged ; ROC Curve ; Reproducibility of Results ; Severity of Illness Index
Substance Nomenclature :
0 (Biomarkers)
0 (Cytokines)
0 (Inflammation Mediators)
Entry Date(s) :
Date Created: 20151015 Date Completed: 20160824 Latest Revision: 20160210
Update Code :
20210210
DOI :
10.1684/ecn.2015.0363
PMID :
26463466
Czasopismo naukowe
Introduction: This study aimed to compare the accuracy of selected laboratory markers in assessing disease activity in patients with ulcerative colitis (UC). The analysis included serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-, IFN-, hsCRP, peripheral regulatory T cells, as well as fecal calprotectin and lactoferrin.
Patients and Methods: A group of 45 adults with UC was enrolled in the study. Disease activity was assessed using the Mayo endoscopic index, while for clinical activity scoring, the Clinical Activity Index (CAI) was used. Concentrations of markers investigated were estimated by means of flow cytometry and enzyme-linked immunosorbent assays: the results were correlated with both indices.
Results: The study demonstrated that both fecal markers, i.e. calprotectin (r = 0.880, P<0.001) and lactoferrin (r = 0.799, P<0.001) correlated closely with the Mayo endoscopic score, and might be used to evaluate the severity of UC in the clinical setting. The correlation of these markers with CAI was also significant, with r = 0.831 for calprotectin (P<0.001) and r = 0.672 for lactoferrin (P<0.05). As for the other markers investigated, only IL-6 (r = 0.598, P<0.001), IL-17A (r = 0.587, P<0.005), and TNF- (r = 0.701, P<0.001) correlated closely with the Mayo endoscopic index. The correlation of the markers with CAI was also significant, though weaker, with r = 0.525 for IL-6 (P<0.001), r = 0.587 for IL-17A (P<0.05), and r = 0.624 for TNF- (P<0.001).
Discussion: Despite the fact, that UC is generally considered to be an IL-13-driven, Th2-like type of disease, markers of inflammation such as serum interleukin (IL)-6, IL-17, TNF-, fecal calprotectin and lactoferrin might be useful in assessing disease activity.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies