Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Increased risk of death due to heart disease after radiotherapy for esophageal cancer.

Tytuł :
Increased risk of death due to heart disease after radiotherapy for esophageal cancer.
Autorzy :
Frandsen J; 1 Radiation Oncology Department, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA ; 2 Division of Cardiology, University of Utah, University Hospital, Salt Lake City, UT 84112, USA.
Boothe D; 1 Radiation Oncology Department, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA ; 2 Division of Cardiology, University of Utah, University Hospital, Salt Lake City, UT 84112, USA.
Gaffney DK; 1 Radiation Oncology Department, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA ; 2 Division of Cardiology, University of Utah, University Hospital, Salt Lake City, UT 84112, USA.
Wilson BD; 1 Radiation Oncology Department, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA ; 2 Division of Cardiology, University of Utah, University Hospital, Salt Lake City, UT 84112, USA.
Lloyd S; 1 Radiation Oncology Department, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA ; 2 Division of Cardiology, University of Utah, University Hospital, Salt Lake City, UT 84112, USA.
Pokaż więcej
Źródło :
Journal of gastrointestinal oncology [J Gastrointest Oncol] 2015 Oct; Vol. 6 (5), pp. 516-23.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Hong Kong : AME Publishing Group
Original Publication: Hong Kong : Pioneer Bioscience Pub. Co.
References :
Int J Radiat Oncol Biol Phys. 2012 Aug 1;83(5):1580-6. (PMID: 22284687)
N Engl J Med. 1996 Aug 15;335(7):462-7. (PMID: 8672151)
Br J Cancer. 2013 Jan 15;108(1):179-82. (PMID: 23257897)
Med Dosim. 2007 Fall;32(3):166-71. (PMID: 17707195)
J Clin Oncol. 2014 Feb 10;32(5):385-91. (PMID: 24419108)
Int J Cardiovasc Imaging. 2009 Jun;25(5):487-95. (PMID: 19234869)
Cancer. 1992 Mar 1;69(5):1241-7. (PMID: 1739922)
Dis Esophagus. 2010 May;23(4):300-8. (PMID: 19732129)
Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1078-85. (PMID: 22867894)
Circulation. 1998 May 12;97(18):1837-47. (PMID: 9603539)
JAMA. 1993 Oct 27;270(16):1949-55. (PMID: 8411552)
Lancet Oncol. 2007 Mar;8(3):226-34. (PMID: 17329193)
JAMA. 1999 May 5;281(17):1623-7. (PMID: 10235156)
Ann Surg. 1981 Oct;194(4):438-46. (PMID: 7283505)
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S77-85. (PMID: 20171522)
J Natl Cancer Inst. 2007 Feb 7;99(3):206-14. (PMID: 17284715)
J Natl Cancer Inst. 2007 Mar 7;99(5):365-75. (PMID: 17341728)
Dis Esophagus. 2005;18(6):400-5. (PMID: 16336612)
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):707-14. (PMID: 18191334)
J Clin Oncol. 2007 Jan 1;25(1):43-9. (PMID: 17194904)
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9. (PMID: 20171502)
Tumori. 1984 Jun 30;70(3):235-6. (PMID: 6588670)
Circulation. 2004 Jun 29;109(25):3122-31. (PMID: 15226229)
N Engl J Med. 2012 May 31;366(22):2074-84. (PMID: 22646630)
Semin Radiat Oncol. 2003 Jul;13(3):346-56. (PMID: 12903022)
J Natl Cancer Inst Monogr. 1993;(15):117-30. (PMID: 7912518)
Circulation. 2007 Feb 6;115(5):e69-171. (PMID: 17194875)
J Support Oncol. 2008 Jan;6(1):41-8. (PMID: 18257400)
BMJ. 2009 Dec 08;339:b4606. (PMID: 19996459)
J Clin Oncol. 2003 Sep 15;21(18):3431-9. (PMID: 12885835)
JAMA. 2007 Feb 14;297(6):611-9. (PMID: 17299196)
Technol Cancer Res Treat. 2011 Oct;10(5):487-94. (PMID: 21895033)
N Engl J Med. 2006 Jul 6;355(1):11-20. (PMID: 16822992)
Expert Opin Drug Saf. 2009 Mar;8(2):191-202. (PMID: 19309247)
N Engl J Med. 2013 Mar 14;368(11):987-98. (PMID: 23484825)
Contributed Indexing :
Keywords: Esophageal cancer (EC); heart disease; radiation therapy (RT)
Entry Date(s) :
Date Created: 20151022 Date Completed: 20151021 Latest Revision: 20200930
Update Code :
20210210
PubMed Central ID :
PMC4570919
DOI :
10.3978/j.issn.2078-6891.2015.040
PMID :
26487946
Czasopismo naukowe
Objective: To evaluate the risk of heart disease related death (HDRD) following radiation therapy (RT) for esophageal cancer (EC).
Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, two cohorts of patients with EC were created: (I) patients who received RT with their initial therapy; and (II) those who did not. Heart disease specific survival (HDSS) was analyzed using Kaplan-Meier methods. Cox proportional-hazards regression methods were used for univariate and multivariate analyses.
Results: We identified 40,778 patients with EC. A total of 26,377 patients received RT and 14,401 did not. HDSS analysis revealed increased risk of HDRD in those receiving RT (P<0.05), with an absolute risk of HDRD of 2.8%, 5.3% and 9.4% at 5-, 10- and 20-year, respectively. Log rank test of HDSS revealed the risk of HDRD became significant at 8 months (P<0.05). The following were associated with HDRD: RT, age, race, stage at presentation, time period of diagnosis, and known comorbid condition keeping one from esophagectomy. On multivariate analysis, RT remained predictive of HDRD [hazard ratio (HR) 1.46, P<0.05]. When considering only candidates for definitive therapy, RT remained predictive of HDRD on univariate (HR 1.53, P<0.0001) and multivariate (HR 1.62, P<0.0001) analyses.
Conclusions: The use of RT leads to increased risk of HDRD that is detectable as early as eight months from diagnosis. More research is needed to define optimal dose volume parameters to prevent cardiac death. Consideration should be given to this risk in relation to prognosis and the expected benefits of RT.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies