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Tytuł pozycji:

Pharmacokinetic considerations in the use of antivirals in neonates.

Tytuł:
Pharmacokinetic considerations in the use of antivirals in neonates.
Autorzy:
Enioutina EY; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.; b Division of Microbiology and Immunology, Department of Pathology , University of Utah School of Medicine , 15 North Medical Drive East, Salt Lake City , UT 84112 , USA.
Constance JE; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Stockmann C; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Linakis MW; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Yu T; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Rower JE; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Balch AH; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Sherwin CM; a Division of Clinical Pharmacology, Department of Pediatrics , University of Utah School of Medicine , 295 Chipeta Way, Salt Lake City , UT 84108 , USA.
Źródło:
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2015; Vol. 11 (12), pp. 1861-78. Date of Electronic Publication: 2015 Nov 04.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: London : Informa Healthcare
Original Publication: London : Ashley Publications, Ltd., c2005-
MeSH Terms:
Antiviral Agents/*pharmacokinetics
Immune System/*physiology
Virus Diseases/*drug therapy
Adult ; Age Factors ; Animals ; Antiviral Agents/administration & dosage ; Child ; Disease Susceptibility/immunology ; Dose-Response Relationship, Drug ; Humans ; Infant, Newborn ; Infant, Premature ; Virus Diseases/epidemiology ; Virus Diseases/immunology
Contributed Indexing:
Keywords: :antiviral drugs; HIV; enteroviruses; herpes viruses; influenza; neonates; pharmacokinetics of antiviral drugs in neonates
Substance Nomenclature:
0 (Antiviral Agents)
Entry Date(s):
Date Created: 20151105 Date Completed: 20160706 Latest Revision: 20170720
Update Code:
20240104
DOI:
10.1517/17425255.2015.1108963
PMID:
26535960
Czasopismo naukowe
Introduction: Neonatal patients, because of the inability of their immune system to properly respond to microbial challenge, are highly susceptible to viral infections. Immunoglobulins, monoclonal antibody and antiviral drugs are used for prophylaxis and treatment of viral diseases in neonates. Neonates and, especially, preterm infants differ in drug absorption, distribution, metabolism and excretion from adults and older children.
Areas Covered: This review will evaluate deficiencies of neonatal immune responses to microbial challenge that predispose newborns to viral infections, clinical manifestations and the treatment of viral diseases in neonates. We focus on published studies describing antiviral drug pharmacokinetics in neonates and make recommendations on the dosing of these drugs, allowing achievement of maximal clinical benefits in neonates.
Expert Opinion: While some efforts were undertaken to study pharmacokinetics and pharmacodynamics of antiviral drugs, much more needs to be done. Current data indicate that the pharmacokinetics of antiviral drugs may vary significantly depending on gestational age, maturation processes of drug-metabolizing enzymes and renal clearance. Specifics of pharmacokinetics of antiviral drugs need to be taken into consideration when they are prescribed to neonates and infants.

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