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Tytuł pozycji:

Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6).

Tytuł :
Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6).
Autorzy :
Cuviello F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Tellgren-Roth Å; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Lara P; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Ruud Selin F; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Monné M; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Nilsson I; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. Electronic address: .
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy. Electronic address: .
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Źródło :
FEBS letters [FEBS Lett] 2015 Dec 21; Vol. 589 (24 Pt B), pp. 3921-8. Date of Electronic Publication: 2015 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd.
Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies.
MeSH Terms :
Intracellular Membranes/*metabolism
Multidrug Resistance-Associated Proteins/*chemistry
Multidrug Resistance-Associated Proteins/*metabolism
Endoplasmic Reticulum/metabolism ; Humans ; Multidrug Resistance-Associated Proteins/genetics ; Protein Structure, Tertiary ; Protein Transport ; Sequence Deletion
Contributed Indexing :
Keywords: ABCC6; ATP-binding cassette transporter; Membrane protein insertion; Multidrug-resistance associated protein 6; Pseudoxanthoma elasticum; Transmembrane domain
Substance Nomenclature :
0 (ABCC6 protein, human)
0 (Multidrug Resistance-Associated Proteins)
Entry Date(s) :
Date Created: 20151108 Date Completed: 20160510 Latest Revision: 20151222
Update Code :
20210623
DOI :
10.1016/j.febslet.2015.10.030
PMID :
26545497
Czasopismo naukowe
The function of the ATP-binding cassette transporter MRP6 is unknown but mutations in its gene cause pseudoxanthoma elasticum. We have investigated the membrane topology of the N-terminal transmembrane domain TMD0 of MRP6 and the membrane integration and orientation propensities of its transmembrane segments (TMs) by glycosylation mapping. Results demonstrate that TMD0 has five TMs, an Nout-Cin topology and that the less hydrophobic TMs have strong preference for their orientation in the membrane that affects the neighboring TMs. Two disease-causing mutations changing the number of positive charges in the loops of TMD0 did not affect the membrane insertion efficiencies of the adjacent TMs.
(Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)

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