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Tytuł:
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Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis.
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Autorzy:
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Bourke L; Health and Wellbeing Research Institute, Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield, UK. Electronic address: .
Smith D; Geography & Environment, University of Southampton, Southampton, UK.
Steed L; Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Hooper R; Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Carter A; Health and Wellbeing Research Institute, Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield, UK.
Catto J; Academic Urology Unit and Institute for Cancer Studies, The Medical School, University of Sheffield, Sheffield, UK.
Albertsen PC; Department of Surgery, Division of Urology, University of Connecticut Health Center, Farmington, CT, USA.
Tombal B; University Clinics Saint Luc/Catholic University of Louvain, Brussels, Belgium.
Payne HA; Department of Oncology, University College London Hospitals, London, UK.
Rosario DJ; Department of Oncology, University of Sheffield, Sheffield, UK.
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Źródło:
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European urology [Eur Urol] 2016 Apr; Vol. 69 (4), pp. 693-703. Date of Electronic Publication: 2015 Nov 26.
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Typ publikacji:
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Journal Article; Meta-Analysis; Review; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: 2002- : Amsterdam : Elsevier Science
Original Publication: Basel, New York, Karger.
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MeSH Terms:
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Exercise Therapy*/adverse effects
Quality of Life*
Fatigue/*therapy
Prostatic Neoplasms/*therapy
Chi-Square Distribution ; Fatigue/physiopathology ; Fatigue/psychology ; Health Status ; Humans ; Male ; Muscle Strength ; Neoplasm Staging ; Odds Ratio ; Physical Fitness ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/physiopathology ; Prostatic Neoplasms/psychology ; Risk Factors ; Time Factors ; Treatment Outcome
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Grant Information:
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RP-DG-1213-10010 United Kingdom DH_ Department of Health
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Contributed Indexing:
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Keywords: Adverse effects; Exercise; Fatigue; Prostate cancer; Quality of life
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Entry Date(s):
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Date Created: 20151204 Date Completed: 20161213 Latest Revision: 20220409
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Update Code:
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20240104
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DOI:
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10.1016/j.eururo.2015.10.047
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PMID:
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26632144
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Context: Exercise could be beneficial for prostate cancer survivors. However, no systematic review across cancer stages and treatment types addressing potential benefits and harms exists to date.
Objective: To assess the effects of exercise on cancer-specific quality of life and adverse events in prostate cancer trials.
Evidence Acquisition: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis.
Evidence Synthesis: We included 16 randomised controlled trials (RCTs) involving 1574 men with prostate cancer. Follow-up varied from 8 wk to 12 mo. RCTs involved men with stage I-IV cancers. A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 men measured cancer-specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome (SMD 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate (SMD 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for cancer-specific fatigue, submaximal fitness, and lower body strength. We found no evidence of benefit for disease progression, cardiovascular health, or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, myocardial infarction) were equivalent to those seen in controls.
Conclusions: These results support the hypothesis that exercise interventions improve cancer-specific quality of life, cancer-specific fatigue, submaximal fitness, and lower body strength.
Patient Summary: This review shows that exercise/physical activity interventions can improve quality of life, fatigue, fitness, and function for men with prostate cancer.
(Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
