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Tytuł pozycji:

The Role of the Fibroblast in Inflammatory Upper Airway Conditions.

Tytuł:
The Role of the Fibroblast in Inflammatory Upper Airway Conditions.
Autorzy:
Ball SL; Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Otolaryngology Head and Neck Surgery, Freeman Hospital, Newcastle upon Tyne, United Kingdom. Electronic address: .
Mann DA; Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Wilson JA; Department of Otolaryngology Head and Neck Surgery, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
Fisher AJ; Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Źródło:
The American journal of pathology [Am J Pathol] 2016 Feb; Vol. 186 (2), pp. 225-33. Date of Electronic Publication: 2015 Dec 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Publication: 2011-: New York : Elsevier
Original Publication: Philadelphia [etc.] American Assn. of Pathologists [etc.]
MeSH Terms:
Airway Remodeling/*immunology
Asthma/*immunology
Fibroblasts/*cytology
Inflammation/*immunology
Respiratory System/*immunology
Animals ; Cytokines/immunology ; Fibroblasts/immunology ; Humans
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Grant Information:
United Kingdom WT_ Wellcome Trust; 100201/Z/12/A United Kingdom WT_ Wellcome Trust
Substance Nomenclature:
0 (Cytokines)
Entry Date(s):
Date Created: 20151222 Date Completed: 20160614 Latest Revision: 20210109
Update Code:
20240104
PubMed Central ID:
PMC4729240
DOI:
10.1016/j.ajpath.2015.09.020
PMID:
26687989
Czasopismo naukowe
Upper airway inflammation is one of the most frequent health care presentations. This is perhaps not surprising with our exposure to a myriad of environmental microbes, pollutants, and allergens. The precise pathophysiological mechanisms that cause persistent, exaggerated, upper airway inflammation rather than acute resolving illness remain unclear. Analysis of upper airway specimens identifies specific inflammatory cells, cytokine signatures, and fibrotic airway remodeling. Recent research has highlighted the role of stromal cells in the generation and persistence of chronic inflammation. Rather than simply being scaffolding or extracellular matrix-secreting cells on which organ systems are built, stromal cells including fibroblasts and osteocytes have their own independent immunologic functions. Here, we review the emerging inflammatory roles of upper airway fibroblasts, the majority of which appear to influence immune cell chemotaxis and amplify the inflammatory response.
(Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)

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