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Tytuł pozycji:

Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.

Tytuł :
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
Autorzy :
Rocha-Pereira J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Van Dycke J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Neyts J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec 28; Vol. 60 (3), pp. 1907-11. Date of Electronic Publication: 2015 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Washington, American Society for Microbiology
MeSH Terms :
Caliciviridae Infections/*drug therapy
Cytidine/*analogs & derivatives
Gastroenteritis/*drug therapy
Norovirus/*drug effects
Virus Shedding/*drug effects
Amides/therapeutic use ; Animals ; Caliciviridae Infections/virology ; Cytidine/therapeutic use ; Disease Models, Animal ; Feces/virology ; Gastroenteritis/virology ; Mice ; Mice, Knockout ; Norovirus/growth & development ; Pyrazines/therapeutic use ; Receptors, Interferon/genetics ; Transplant Recipients
References :
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Substance Nomenclature :
0 (Amides)
0 (Pyrazines)
0 (Receptors, Interferon)
27FS20C1D8 (2'-C-methylcytidine)
5CSZ8459RP (Cytidine)
EW5GL2X7E0 (favipiravir)
Entry Date(s) :
Date Created: 20151230 Date Completed: 20161213 Latest Revision: 20181113
Update Code :
20210914
PubMed Central ID :
PMC4776014
DOI :
10.1128/AAC.02198-15
PMID :
26711754
Czasopismo naukowe
Prolonged norovirus shedding may occur in certain patients, such as organ transplant recipients. We established a mouse model for persistent norovirus infection (using the mouse norovirus MNV.CR6 strain). The nucleoside viral polymerase inhibitor 2'-C-methylcytidine (2CMC), but not favipiravir (T-705), reduced viral shedding to undetectable levels. Viral rebound was observed after stopping treatment, which was again effectively controlled by treatment with 2CMC. No drug-resistant variants emerged.
(Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

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