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Tytuł pozycji:

Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.

Tytuł :
Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.
Autorzy :
Kochetkova OY; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. .; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. .
Yurinskaya MM; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Evgen'ev MB; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Zatsepina OG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Shabarchina LI; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Suslikov AV; Hospital of the Pushchino Scientific Center, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Tikhonenko SA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Vinokurov MG; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
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Źródło :
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2015 Nov; Vol. 465 (1), pp. 299-302. Date of Electronic Publication: 2016 Jan 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: New York, Consultants Bureau c1965-
MeSH Terms :
Drug Delivery Systems*
HSP70 Heat-Shock Proteins/*administration & dosage
Phagocytes/*drug effects
Tumor Necrosis Factor-alpha/*metabolism
Apoptosis/drug effects ; Cell Line ; Drug Compounding ; HSP70 Heat-Shock Proteins/chemistry ; Humans ; Immunity, Innate/drug effects ; Monocytes/drug effects ; Neutrophils/drug effects ; Reactive Oxygen Species/metabolism
References :
J Biol Chem. 2002 Apr 26;277(17):15028-34. (PMID: 11836257)
Biomacromolecules. 2010 May 10;11(5):1241-7. (PMID: 20405818)
Nat Biotechnol. 2003 Oct;21(10):1184-91. (PMID: 14520404)
Langenbecks Arch Surg. 2010 Aug;395(6):597-605. (PMID: 20582603)
J Leukoc Biol. 2003 Feb;73(2):209-12. (PMID: 12554797)
Angew Chem Int Ed Engl. 2009;48(45):8485-9. (PMID: 19810070)
Dokl Biol Sci. 2013 Sep;452:305-9. (PMID: 24150653)
Biomed Khim. 2007 Nov-Dec;53(6):662-71. (PMID: 18323151)
Langmuir. 2004 Apr 13;20(8):3398-406. (PMID: 15875874)
Ann N Y Acad Sci. 2010 Jun;1197:94-107. (PMID: 20536838)
Dokl Biochem Biophys. 2010 Nov-Dec;435:316-9. (PMID: 21184302)
Substance Nomenclature :
0 (HSP70 Heat-Shock Proteins)
0 (Reactive Oxygen Species)
0 (Tumor Necrosis Factor-alpha)
Entry Date(s) :
Date Created: 20160105 Date Completed: 20161007 Latest Revision: 20181113
Update Code :
20210210
DOI :
10.1134/S001249661506006X
PMID :
26725241
Czasopismo naukowe
Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

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