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Tytuł pozycji:

Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization.

Tytuł :
Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization.
Autorzy :
Duncan DR; Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, MA †Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee ‡Clinical Research Program, Boston Children's Hospital, MA §Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, MA.
Amirault J
Johnston N
Mitchell P
Larson K
Rosen RL
Pokaż więcej
Źródło :
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2016 Aug; Vol. 63 (2), pp. 210-7.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Publication: 1998- : Philadelphia, PA : Lippincott Williams & Wilkins
Original Publication: [New York, N.Y.] : Raven Press, [c1982-
MeSH Terms :
Gastroesophageal Reflux/*diagnosis
Hospitalization/*statistics & numerical data
Respiratory Aspiration/*etiology
Adolescent ; Boston ; Child ; Child, Preschool ; Cost of Illness ; Female ; Follow-Up Studies ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/therapy ; Hospitals, Pediatric ; Humans ; Infant ; Male ; Prognosis ; Prospective Studies ; Respiratory Aspiration/therapy ; Risk Assessment
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Grant Information :
P30 DK034854 United States DK NIDDK NIH HHS; R01 DK097112 United States DK NIDDK NIH HHS
Entry Date(s) :
Date Created: 20160123 Date Completed: 20171227 Latest Revision: 20181113
Update Code :
20210210
PubMed Central ID :
PMC4917472
DOI :
10.1097/MPG.0000000000001092
PMID :
26794490
Czasopismo naukowe
Objectives: Gastroesophageal reflux is common but remains a controversial disease to diagnose and treat and little is known about the role of reflux testing in predicting clinical outcomes, particularly in children at risk for extraesophageal reflux complications. The aim of this study was to determine if rates of hospitalization were affected by reflux burden even after adjusting for aspiration risk.
Methods: We prospectively recruited, between 2009 and 2014, a cohort of pediatric patients with suspected extraesophageal reflux disease who were referred for reflux testing and underwent both multichannel intraluminal impedance with pH (pH-MII) and modified barium swallow studies. A subset of patients also underwent bronchoalveolar lavage with pepsin analysis. We determined their rates of hospitalization for a minimum of 1 year following pH-MII testing.
Results: We prospectively enrolled 116 pediatric patients who presented for care at Boston Children's Hospital and underwent both pH-MII and modified barium swallow studies. There was no statistically significant relationship between reflux burden measured by pH-MII or bronchoalveolar pepsin and total number of admissions or number of admission nights even after adjusting for aspiration status (P > 0.2). There were no statistically significant relationships between reflux burden by any method and the number or nights of urgent pulmonary admissions before or after adjusting for aspiration risk (P > 0.08).
Conclusions: Even in aspirating children, reflux burden did not increase the risk of hospitalization. Based on these results, routine reflux testing cannot be recommended even in aspirating children, because the results do not impact clinically significant outcomes.

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