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Tytuł pozycji:

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

Tytuł :
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Autorzy :
Ceccarelli M; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar; Department of Science and Technology, University of Sannio, Benevento 82100, Italy.
Barthel FP; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Oncology Graduate School Amsterdam, Department of Pathology, VU University Medical Center, 1081 HV Amsterdam, the Netherlands.
Malta TM; Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Monte Alegre, Ribeirão Preto-SP CEP: 14049-900, Brazil; Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
Sabedot TS; Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Monte Alegre, Ribeirão Preto-SP CEP: 14049-900, Brazil; Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
Salama SR; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Murray BA; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Morozova O; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Newton Y; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Radenbaugh A; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Pagnotta SM; Department of Science and Technology, University of Sannio, Benevento 82100, Italy; BIOGEM Istituto di Ricerche Genetiche 'G. Salvatore,' Campo Reale, 83031 Ariano Irpino, Italy.
Anjum S; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha P.O. box 5825, Qatar.
Wang J; Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA.
Manyam G; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zoppoli P; Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA.
Ling S; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rao AA; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Grifford M; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Cherniack AD; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Zhang H; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Poisson L; Henry Ford Hospital, Detroit, MI 48202, USA.
Carlotti CG Jr; Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Monte Alegre, Ribeirão Preto-SP CEP: 14049-900, Brazil; Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
Tirapelli DP; Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Monte Alegre, Ribeirão Preto-SP CEP: 14049-900, Brazil; Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
Rao A; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mikkelsen T; Henry Ford Hospital, Detroit, MI 48202, USA.
Lau CC; Texas Children's Hospital, Houston, TX 77030, USA; Baylor College of Medicine, Houston, TX 77030, USA.
Yung WK; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rabadan R; Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA.
Huse J; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Brat DJ; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Lehman NL; Department of Pathology, The Ohio State University, Columbus, OH 43210, USA.
Barnholtz-Sloan JS; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Zheng S; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hess K; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rao G; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Meyerson M; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Beroukhim R; The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
Cooper L; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Akbani R; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wrensch M; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
Haussler D; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Aldape KD; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Laird PW; Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Gutmann DH; School of Medicine, Washington University, St. Louis, MO 63110, USA.
Noushmehr H; Department of Genetics (CISBi/NAP), Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Monte Alegre, Ribeirão Preto-SP CEP: 14049-900, Brazil; Center for Integrative Systems Biology (CISBi, NAP/USP), Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil. Electronic address: .
Iavarone A; Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Department of Systems Biology and Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: .
Verhaak RG; Department of Genomic Medicine, Department of Bioinformatics and Computational Biology, Department of Biostatistics, Department of Neuro-Oncology, Department of Neurosurgery, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: .
Pokaż więcej
Corporate Authors :
TCGA Research Network
Źródło :
Cell [Cell] 2016 Jan 28; Vol. 164 (3), pp. 550-63.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język :
English
Imprint Name(s) :
Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
MeSH Terms :
Transcriptome*
Brain Neoplasms/*genetics
Brain Neoplasms/*pathology
Glioma/*genetics
Glioma/*pathology
Adult ; Brain Neoplasms/metabolism ; Cell Proliferation ; Cluster Analysis ; DNA Helicases/genetics ; DNA Methylation ; Epigenesis, Genetic ; Glioma/metabolism ; Humans ; Isocitrate Dehydrogenase/genetics ; Middle Aged ; Mutation ; Nuclear Proteins/genetics ; Promoter Regions, Genetic ; Signal Transduction ; Telomerase/genetics ; Telomere ; X-linked Nuclear Protein
References :
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Grant Information :
U24CA143840 United States CA NCI NIH HHS; R01 CA176659 United States CA NCI NIH HHS; R01 CA188743 United States CA NCI NIH HHS; R01CA185486 United States CA NCI NIH HHS; U24CA126561 United States CA NCI NIH HHS; P30 CA016672 United States CA NCI NIH HHS; U24 CA143882 United States CA NCI NIH HHS; R01 CA185486 United States CA NCI NIH HHS; U54 HG003067 United States HG NHGRI NIH HHS; U54HG003273 United States HG NHGRI NIH HHS; U24 CA143835 United States CA NCI NIH HHS; R01 CA190121 United States CA NCI NIH HHS; U24CA143731 United States CA NCI NIH HHS; R01 CA179044 United States CA NCI NIH HHS; U24CA126551 United States CA NCI NIH HHS; U24CA126543 United States CA NCI NIH HHS; U24CA126554 United States CA NCI NIH HHS; U24 CA143866 United States CA NCI NIH HHS; U24CA143858 United States CA NCI NIH HHS; U24CA126544 United States CA NCI NIH HHS; P30CA016672 United States CA NCI NIH HHS; U24CA143882 United States CA NCI NIH HHS; U24 CA126551 United States CA NCI NIH HHS; U24CA144025 United States CA NCI NIH HHS; U54CA193313 United States CA NCI NIH HHS; U54HG003067 United States HG NHGRI NIH HHS; U24 CA143845 United States CA NCI NIH HHS; U24 CA143799 United States CA NCI NIH HHS; T32 GM007753 United States GM NIGMS NIH HHS; U54 HG003273 United States HG NHGRI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; U24 CA144025 United States CA NCI NIH HHS; U24CA143883 United States CA NCI NIH HHS; U54HG003079 United States HG NHGRI NIH HHS; U24 CA126554 United States CA NCI NIH HHS; U24 CA180951 United States CA NCI NIH HHS; U24 CA143840 United States CA NCI NIH HHS; U24 CA143843 United States CA NCI NIH HHS; P50 CA097257 United States CA NCI NIH HHS; U24CA143867 United States CA NCI NIH HHS; R01CA179044 United States CA NCI NIH HHS; U24CA143835 United States CA NCI NIH HHS; U24 CA126561 United States CA NCI NIH HHS; U24 CA143858 United States CA NCI NIH HHS; U54 CA193313 United States CA NCI NIH HHS; U24CA143843 United States CA NCI NIH HHS; R01 NS081125 United States NS NINDS NIH HHS; U24 CA143848 United States CA NCI NIH HHS; U24 CA126543 United States CA NCI NIH HHS; U24CA143848 United States CA NCI NIH HHS; U24CA126563 United States CA NCI NIH HHS; U24CA126546 United States CA NCI NIH HHS; U54 HG003079 United States HG NHGRI NIH HHS; U24CA143799 United States CA NCI NIH HHS; U54 HG007990 United States HG NHGRI NIH HHS; U24 CA143883 United States CA NCI NIH HHS; F30 CA192725 United States CA NCI NIH HHS; U24CA143866 United States CA NCI NIH HHS; U24CA143845 United States CA NCI NIH HHS; P50 CA127001 United States CA NCI NIH HHS; P01 CA085878 United States CA NCI NIH HHS; U24 CA143867 United States CA NCI NIH HHS; U24 CA126546 United States CA NCI NIH HHS; U24 CA126563 United States CA NCI NIH HHS; U24 CA126544 United States CA NCI NIH HHS; R01 CA052689 United States CA NCI NIH HHS
Contributed Indexing :
Investigator: S Anjum; H Arachchi; JT Auman; M Balasundaram; S Balu; G Barnett; S Baylin; S Bell; C Benz; N Bir; KL Black; T Bodenheimer; L Boice; MS Bootwalla; J Bowen; CA Bristow; YS Butterfield; QR Chen; L Chin; J Cho; E Chuah; S Chudamani; SG Coetzee; ML Cohen; H Colman; M Couce; F D'Angelo; T Davidsen; A Davis; JA Demchok; K Devine; L Ding; R Duell; JB Elder; JM Eschbacher; A Fehrenbach; M Ferguson; S Frazer; G Fuller; J Fulop; SB Gabriel; L Garofano; JM Gastier-Foster; N Gehlenborg; M Gerken; G Getz; C Giannini; WJ Gibson; A Hadjipanayis; DN Hayes; DI Heiman; B Hermes; J Hilty; KA Hoadley; AP Hoyle; M Huang; SR Jefferys; CD Jones; SJ Jones; Z Ju; A Kastl; A Kendler; J Kim; R Kucherlapati; PH Lai; MS Lawrence; S Lee; KM Leraas; TM Lichtenberg; P Lin; Y Liu; J Liu; JY Ljubimova; Y Lu; Y Ma; DT Maglinte; HS Mahadeshwar; MA Marra; M McGraw; C McPherson; S Meng; PA Mieczkowski; CR Miller; GB Mills; RA Moore; LE Mose; AJ Mungall; R Naresh; T Naska; L Neder; MS Noble; A Noss; BP O'Neill; QT Ostrom; C Palmer; A Pantazi; M Parfenov; PJ Park; JS Parker; CM Perou; CR Pierson; T Pihl; A Protopopov; A Radenbaugh; NC Ramirez; WK Rathmell; X Ren; J Roach; AG Robertson; G Saksena; JE Schein; SE Schumacher; J Seidman; K Senecal; S Seth; H Shen; Y Shi; J Shih; K Shimmel; H Sicotte; S Sifri; T Silva; JV Simons; R Singh; T Skelly; AE Sloan; HJ Sofia; MG Soloway; X Song; C Sougnez; C Souza; SM Staugaitis; H Sun; C Sun; D Tan; J Tang; Y Tang; L Thorne; FA Trevisan; T Triche; DJ Van Den Berg; U Veluvolu; D Voet; Y Wan; Z Wang; R Warnick; JN Weinstein; DJ Weisenberger; MD Wilkerson; F Williams; L Wise; Y Wolinsky; J Wu; AW Xu; L Yang; L Yang; TI Zack; JC Zenklusen; J Zhang; W Zhang; J Zhang; E Zmuda
Substance Nomenclature :
0 (Nuclear Proteins)
EC 1.1.1.41 (Isocitrate Dehydrogenase)
EC 2.7.7.49 (TERT protein, human)
EC 2.7.7.49 (Telomerase)
EC 3.6.4.- (DNA Helicases)
EC 3.6.4.12 (ATRX protein, human)
EC 3.6.4.12 (X-linked Nuclear Protein)
Entry Date(s) :
Date Created: 20160130 Date Completed: 20160609 Latest Revision: 20190125
Update Code :
20210623
PubMed Central ID :
PMC4754110
DOI :
10.1016/j.cell.2015.12.028
PMID :
26824661
Czasopismo naukowe
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.
(Copyright © 2016 Elsevier Inc. All rights reserved.)

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