Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.

Szczegóły
Abstrakt

Tytuł:: Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.
Autorzy:: Stasiak M; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.; Department of Cytobiology and Proteomics, Medical University of Lodz, Lodz, Poland.
Boncela J; Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Perreau C; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.
Karamanou K; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.; Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.
Chatron-Colliet A; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.
Proult I; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.
Przygodzka P; Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Chakravarti S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Maquart FX; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.; CHU de Reims, Laboratoire Central de Biochimie, Reims, France.
Kowalska MA; Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Wegrowski Y; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.
Brézillon S; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire, Reims, France.
Źródło:: PloS one [PLoS One] 2016 Mar 01; Vol. 11 (3), pp. e0150226. Date of Electronic Publication: 2016 Mar 01 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Cell Movement/*drug effects
Chondroitin Sulfate Proteoglycans/*pharmacology
Keratan Sulfate/*pharmacology
Matrix Metalloproteinase 14/*metabolism
Melanoma/*metabolism
Transcription Factors/*metabolism
Cell Line, Tumor ; Cell Movement/physiology ; HT29 Cells ; Humans ; Lumican ; Melanoma/pathology ; Snail Family Transcription Factors
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Grant Information:: R01 EY011654 United States EY NEI NIH HHS; R56 EY011654 United States EY NEI NIH HHS; EY11654 United States EY NEI NIH HHS
Substance Nomenclature:: 0 (Chondroitin Sulfate Proteoglycans)
0 (LUM protein, human)
0 (Lumican)
0 (Snail Family Transcription Factors)
0 (Transcription Factors)
9056-36-4 (Keratan Sulfate)
EC 3.4.24.80 (Matrix Metalloproteinase 14)
Entry Date(s):: Date Created: 20160302 Date Completed: 20160726 Latest Revision: 20181113
Update Code:: 20240104
PubMed Central ID:: PMC4773148
DOI:: 10.1371/journal.pone.0150226
PMID:: 26930497
: Czasopismo naukowe

Pełny tekst

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

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