Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn's Disease.

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Abstrakt

Tytuł:: Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn's Disease.
Autorzy:: Kucharski M; Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, Poland; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Karczewski J; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Mańkowska-Wierzbicka D; Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, Poland; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Karmelita-Katulska K; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Kaczmarek E; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Iwanik K; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Rzymski P; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Grzymisławski M; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Linke K; Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, Poland; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Dobrowolska A; Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, Poland; Poznan University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland.
Źródło:: Gastroenterology research and practice [Gastroenterol Res Pract] 2016; Vol. 2016, pp. 7896478. Date of Electronic Publication: 2016 Feb 21.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Cairo : Hindawi Publishing Corporation
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Entry Date(s):: Date Created: 20160322 Date Completed: 20160321 Latest Revision: 20201001
Update Code:: 20240104
PubMed Central ID:: PMC4779516
DOI:: 10.1155/2016/7896478
PMID:: 26997952
: Czasopismo naukowe

Pełny tekst

Background. Assessment of endoscopic activity of Crohn's disease (CD) is of growing importance both in clinical practice and in clinical trials. The study aimed to assess which of the endoscopic indices used for evaluation of mucosal changes correlates with the currently used clinical indices for determination of disease activity and with the results of histopathological examination. Study. A group of 71 patients with CD and 52 individuals without a diagnosis of GI tract disease as a control group were investigated, considering clinical and histological severity of the disease and the severity of inflammatory changes in the bowel. Evaluation was conducted with the use of clinical, endoscopic, and histopathological indices. Endoscopic indices were then correlated with different clinical and histopathological indices with the aim of finding the strongest correlations. Results and Conclusions. Correlation between the clinical disease activity and the severity of endoscopic lesions in CD was shown in this study to be poor. The results also indicate that the optimal endoscopic index used in the diagnostic stage and in the assessment of treatment effects in CD is Simple Endoscopic Score for Crohn's Disease (SES-CD).

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